Ocular toxicities in chimeric antigen receptor T-cell therapy: a real-world study leveraging FAERS database.
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アブストラクト Aim:The purpose of this study was to comprehensively explore the ocular toxicity associated with chimeric antigen receptor (CAR) T-cell therapy. Materials & methods: Data were assembled from the US FDA's Adverse Event Reporting System (FAERS) database from 2017 to 2023. Information component and reporting odds ratio methods were used for signal detection in total/categorized CAR T-cell therapy.Results:A total of 17 positive signals (preferred term) were detected, yet none of them were documented in the product information. Some adverse events were with death outcomes and overlapped a lot with cytokine-release syndrome.Conclusion:The ocular adverse events associated with CAR-T cell therapy are noteworthy, and it is imperative to maintain increased alertness and institute early intervention strategies.ジャーナル名 Immunotherapy 投稿日 2023/12/21 投稿者 Zhao, Na; Hu, Fangyuan; Zhai, Yinghong; Ye, Xia; Ruan, Yiming; Liu, Zhen; Wang, Zhiyan; Shen, Wei; Yuan, Lei 組織名 Ophthalmology Department, Naval Hospital of Eastern Theater of PLA, Zhejiang;Province, Zhoushan, China.;Health Service Department, Naval Hospital of Eastern Theater of PLA, Zhejiang;Clinical Research Unit, School of Medicine, Shanghai Ninth People's Hospital;Affiliated to Shanghai JiaoTong University, Shanghai, China.;Health Service Department, The First Naval Hospital of Southern Theater of PLA,;Guangdong Province, Zhanjiang, China.;Ophthalmology Department, The First Affiliated Hospital of Naval Medical;University, Shanghai, China.;Department of Health Management, Faculty of Military Health Service, Naval;Medical University, Shanghai, China. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/38126138/ -
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