Osteoporotic fracture risk in women with breast cancer treated with aromatase inhibitors: a health insurance claims database study in Japan.
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アブストラクト BACKGROUND:Hormone therapy with aromatase inhibitors (AIs) for estrogen receptor-dependent breast cancer may expose patients to an increased osteoporosis risk. This study was performed to estimate fracture risk in women with breast cancer to whom AIs were prescribed in Japan.METHODS:This retrospective study used data from the Japanese Medical Data Vision database. Women with breast cancer prescribed AIs over a 12-month period were identified and matched to women not prescribed AIs using a propensity score. Fracture rates were estimated by a cumulative incidence function and compared using a cause-specific Cox hazard model. The proportion of women undergoing bone density tests was retrieved.RESULTS:For all fractures sites combined, cumulative fracture incidence at 10 years was 0.19 [95%CI: 0.16-0.22] in women prescribed AIs and 0.18 [95%CI: 0.15-0.21] without AIs. AI prescription was not associated with any changes in risk (adjusted hazard ratio: 1.08 [95%CI: 0.99-1.17] p = 0.08). Women prescribed AI more frequently underwent bone density testing (31.9% [95% CI: 31.2%; 32.6%] versus 2.2% [95% CI: 2.0%; 2.4%]).CONCLUSIONS:The anticipated association between AI exposure and osteoporotic fracture risk in Japanese women with breast cancer was not seen clearly.ジャーナル名 Expert opinion on pharmacotherapy 投稿日 2024/4/8 投稿者 Taguchi, Tetsuya; Matsushima, Hisashi; Kodama, Sho; Okubo, Naoki; Ito, Tetsuo; Ludwikowska, Maja; Fukumoto, Seiji; Matsumoto, Toshio 組織名 Division of Endocrine and Breast Surgery, Kyoto Prefectural University of;Medicine, Kyoto, Japan.;Department of Urology, Tokyo Metropolitan Police Hospital, Tokyo, Japan.;Primary Medical Science Department, Medical Affairs Division, Japan Business;Unit, Daiichi Sankyo Co., Ltd ., Tokyo, Japan.;Data Intelligence Department, Global DX, Daiichi Sankyo Co., Ltd., Tokyo, Japan.;Real World Evidence Group, Putnam, Krakow, Poland.;Tokushima University, Tokushima, Japan. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/38588537/ -
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