| アブストラクト | BACKGROUND: Various surgical methods are available for managing large intracerebral hemorrhage. This study compared the prognosis of patients with spontaneous intracerebral hemorrhage who underwent endoscopic evacuation, stereotactic aspiration, and craniotomy by using a nationwide inpatient database in Japan. METHODS: Using the Diagnosis Procedure Combination database, we identified patients who underwent surgery for spontaneous intracerebral hemorrhage within 48 h after admission between April 2014 and March 2018. Eligible patients were classified into three groups according to the type of surgery (endoscopic surgery, stereotactic surgery, and craniotomy). Propensity score matching weight analysis was conducted to compare poor modified Rankin Scale score at discharge (severe disability or death) and hospitalization cost among the groups. RESULTS: Among 17,860 eligible patients, craniotomy, stereotactic surgery, and endoscopic surgery were performed in 14,354, 474, and 3,032 patients, respectively. In the matching weight analysis, all covariates were well balanced. Compared with the endoscopic surgery group, the proportion of poor prognosis (modified Rankin Scale score at discharge of 5 or 6) was significantly higher in craniotomy groups (odds ratio 2.51, 95% confidence interval 1.11-5.68; p = 0.028). Subgroup analysis based on hemorrhage location and consciousness level at the time of admission showed no significant difference between the surgical procedures. Hospitalization costs were significantly higher in the craniotomy group than in the endoscopic surgery group (difference US $9,724, 95% confidence interval 2,169-17,259; p = 0.011). CONCLUSIONS: Endoscopic surgery for spontaneous intracerebral hemorrhage was associated with improved prognosis compared with craniotomy at the hospital discharge. Future large-scale clinical trials are needed to evaluate the optimal surgical techniques for intracerebral hemorrhage. |
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| ジャーナル名 | Neurocritical care |
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| 投稿日 | 2022/11/9 |
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| 投稿者 | Tahara, Shigeyuki; Hattori, Yujiro; Aso, Shotaro; Uda, Kazuaki; Kumazawa, Ryosuke; Matsui, Hiroki; Fushimi, Kiyohide; Yasunaga, Hideo; Morita, Akio |
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| 組織名 | Department of Neurological Surgery, Graduate School of Medicine, Nippon Medical;School, Tokyo, Japan. tabara@nms.ac.jp.;School, Tokyo, Japan.;Department of Anatomy and Neurobiology, Graduate School of Medicine, Nippon;Medical School, Tokyo, Japan.;Department of Biostatistics and Bioinformatics, Graduate School of Medicine, the;University of Tokyo, Tokyo, Japan.;Health Services Research and Development Center, University of Tsukuba, Ibaraki,;Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, the University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36348138/ |
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