| アブストラクト | BACKGROUND: Parkinson's disease (PD) patients with comorbid cancers are increasing in aging populations. However, little is known about the impact of PD on the outcomes of surgeries to resect these cancers. We sought to clarify the association between PD and discharge status of patients who underwent surgery for gastrointestinal cancers, as the most prevalent malignant neoplasms worldwide. METHODS: We identified patients who underwent surgery for gastric and colorectal cancers between April 01, 2014 and March 31, 2018 using the Diagnosis Procedure Combination database, a nationwide administrative inpatient database in Japan. We then collected data on their sex, age, smoking status, body mass index, activities of daily living, cancer stage, and comorbidities. Multivariable Cox regression analyses were conducted to determine factors that influenced discharge to home. RESULTS: Compared with non-PD patients (n = 272,668), PD patients (n = 1341) were significantly older and less likely to receive laparoscopic surgery, and had lower body mass index, more advanced cancer stage, and lower activities of daily living. The proportions of PD and non-PD patients discharged to home were 80.3% and 96.2%, respectively. The adjusted hazard ratio for discharge to home for PD patients was 0.68 (95% confidence interval, 0.64-0.73; P < 0.001). CONCLUSIONS: Compared with non-PD patients, PD patients were less likely to be discharged to home after surgery for gastrointestinal cancers. The present results may indicate a necessity to improve perioperative care for patients with PD. |
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| ジャーナル名 | Parkinsonism & related disorders |
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| Pubmed追加日 | 2022/2/23 |
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| 投稿者 | Kodama, Satoshi; Jo, Taisuke; Yasunaga, Hideo; Michihata, Nobuaki; Matsui, Hiroki; Kumazawa, Ryosuke; Shirota, Yuichiro; Fushimi, Kiyohide; Toda, Tatsushi; Hamada, Masashi |
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| 組織名 | Department of Neurology, Graduate School of Medicine, The University of Tokyo,;Japan. Electronic address: kodamas-tky@umin.ac.jp.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Japan; Department of Respiratory Medicine, Graduate School;of Medicine, The University of Tokyo, Japan.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Japan.;University of Tokyo, Japan.;Japan; Department of Clinical Laboratory Medicine, Graduate School of Medicine,;The University of Tokyo, Tokyo, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, Tokyo, Japan.;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35193101/ |
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