| アブストラクト | Background: Biological disease-modifying antirheumatic drugs (bDMARDs) are recommended for rheumatoid arthritis (RA), but older patients reportedly experience more adverse events (AEs) and show variable treatment response. The objective of this study was to evaluate AEs and effectiveness of bDMARDs in a cohort of older patients. Methods: AE and treatment effectiveness (based on DAS28 scores) data from a prospective provincial pharmacovigilance program for the years 2006-2009 in patients 55-64, 65-74, and 75+ years of age were compared. An intention to treat analysis with chi-square and unpaired t-testing for significance was performed. Results: There were a total of 333 patients (156 were aged 55-64, 125 were 65-74, 52 were 75+). Those 75+ had higher disease activity and worse functional status at baseline. Among those 75+, AEs with bDMARDs were more common and likely to lead to discontinuation of therapy, be graded as severe, and classified as infectious (p < .05). Remission rate among those 75+ was significantly higher than patients 65-74. Etanercept was the most commonly used drug in all age groups. Conclusion: Patients 75+ treated with bDMARDs are at a significantly greater risk of AEs, including infectious ones. The higher remission found in the oldest age group warrants further study. |
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| ジャーナル名 | Canadian geriatrics journal : CGJ |
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| Pubmed追加日 | 2020/6/5 |
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| 投稿者 | Akter, Ripa; Maksymowych, Walter P; Martin, M Liam; Hogan, David B |
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| 組織名 | Geriatrics, Internal Medicine, Division of Geriatric Medicine, University of;Ottawa, Ottawa, ON, Canada.;Division of Rheumatology, Department of Medicine, Faculty of Medicine &;Dentistry, University of Alberta, Edmonton, AB, Canada.;Division of Rheumatology, Department of Medicine, Cumming School of Medicine,;University of Calgary, Calgary, AB, Canada. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32494334/ |
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