Partner Bereavement and Detection of Dementia: A UK-Based Cohort Study Using Routine Health Data.
BACKGROUND: In the UK, an estimated one third of people with dementia have not received a diagnosis. Good evidence suggests that dementia risk is increased among widowed individuals; however, it is not clear if they are being diagnosed in routine primary care.
OBJECTIVE: This study aimed to investigate if bereavement influenced the probability of having received a dementia diagnosis.
METHODS: A population-based cohort study using UK electronic health records, between 1997 and 2017, among 247,586 opposite-sex partners. Those experiencing partner bereavement were matched (age, sex, and date of bereavement) to a non-bereaved person living in a partnership. Multivariate cox regression was performed.
RESULTS: Partner bereavement was associated with an increased risk of receiving a diagnosis of dementia in the first three months (hazard ratio (HR) 1.43, 95% CI 1.20-1.71) and first six months (HR 1.24, 95% CI 1.09-1.41), while there was a small reduced risk of getting a dementia diagnosis over all follow-up (HR 0.94, 95% CI 0.89-0.98).
CONCLUSIONS: Partner bereavement appears to lead to a short-term increased risk of the surviving partner receiving a diagnosis of dementia, suggesting that bereavement unmasks existing undiagnosed dementia. Over the longer term, however, bereaved individuals are less likely to have a diagnosis of dementia in their health records than non-bereaved individuals.
|ジャーナル名||Journal of Alzheimer's disease : JAD|
|投稿者||Forbes, Harriet J; Wong, Angel Y S; Morton, Caroline; Bhaskaran, Krishnan; Smeeth, Liam; Richards, Marcus; Schmidt, Sigrun A J; Langan, Sinead M; Warren-Gash, Charlotte|
|組織名||London School of Hygiene & Tropical Medicine, London, UK.;MRC Unit for Lifelong Health and Ageing at UCL, University College London,;London, UK.;Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.;Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark.|