| アブストラクト | BACKGROUND: Programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1) inhibitors have reformed the treatment landscape for various malignancies and improved prognosis of patients. However, they also lead to events that although rare may prove to be fatal. RESEARCH DESIGN AND METHODS: Data from July 2014 to June 2022 based on FDA Adverse Event Reporting System (FAERS) were analyzed. The signal index reporting odds ratio (ROR) was used to evaluate the correlation between cardiac AEs and given medications. The indications and the median time to onset (TTO) of different PD-1/PD-L1 inhibitors were compared. RESULTS: Cardiac AEs are rare but may be fatal with particular profiles in primary tumor, onset time, and especially gender. We identified 11,538 reports that were related to cardiotoxicity of PD-1/PD-L1 inhibitors, in which 178 different preferred terms (PTs) were distinguished, and nivolumab reported the most PTs with signal. All targeted medications showed signals in myocardial disorders and pericardial disorders, which tend to occur in the first 1-2 months. Non-small cell neoplasm was the top and common indication during anti-PD-1 or anti-PD-L1 therapy with cardiotoxicity. CONCLUSIONS: This study could help early diagnosis and surveillance of ICIs-related cardiotoxicity. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2023/4/19 |
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| 投稿者 | Wang, Qiaoyun; Xiao, Fengjiao; Zeng, Yanbin; Zhu, Qiaoling; Zhang, Haixia |
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| 組織名 | Department of Pharmacy, China Pharmaceutical University Nanjing Drum Tower;Hospital, Nanjing, Jiangsu Province, China.;School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University,;Nanjing, Jiangsu Province, China.;Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of;Nanjing University Medical School, Nanjing, Jiangsu Province, China.;Nanjing Medical Center for Clinical Pharmacy, Nanjing, Jiangsu Province, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37070426/ |
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