| アブストラクト | BACKGROUND: The perioperative risk of sporadic hemangioblastomas (HBs) and von Hippel-Lindau disease (VHL)-associated hemangioblastomas (VHL-associated HBs) remains unclear due to the rare prevalence of HB. Therefore, this study aimed to clarify risk factors for better surgical management of patients with HBs. METHODS: A retrospective analysis of surgically treated HB patients registered in the Diagnosis Procedure Combination database of Japan, between 2010 and 2015, was performed. Age, sex, sporadic HBs or VHL-associated HBs, medical history, tumor location, hospital case load, postoperative complications, and Barthel index (BI) deterioration were assessed. We also evaluated the outcomes and factors of perioperative BI deterioration. RESULTS: In total, 676 patients with 609 intracranial lesions, 64 spinal lesions, and 3 with both types were eligible. Among them, 618 and 58 patients had sporadic HBs and VHL-associated HBs, respectively. The rates of perioperative BI deterioration were 12.5% and 12.2% for sporadic HBs and VHL-associated HBs, respectively. Perioperative mortality was 1.8% and 0% for sporadic HBs and VHL-associated HBs, respectively. Male sex, old age, high hospital case load, and medical history of diabetes mellitus were significantly associated with perioperative BI deterioration in all cases and sporadic HBs. Only medical history of diabetes mellitus was a significant risk factor for perioperative BI deterioration in VHL-associated HBs. CONCLUSIONS: No differences in perioperative BI deterioration rates between sporadic HBs and VHL-associated HBs were found. However, different risk factors for perioperative BI deterioration were identified. Consideration of these risk factors is recommended in all patients undergoing surgery for HB. |
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| ジャーナル名 | World neurosurgery |
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| 投稿日 | 2022/11/11 |
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| 投稿者 | Hidaka, Toshikazu; Ikawa, Fusao; Michihata, Nobuaki; Onishi, Shumpei; Matsuda, Shingo; Ozono, Iori; Oku, Shinichiro; Takayanagi, Shunsaku; Fushimi, Kiyohide; Yasunaga, Hideo; Kurisu, Kaoru; Horie, Nobutaka |
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| 組織名 | Department of Neurosurgery, Shimane Prefectural Central Hospital, Izumo, Japan.;Department of Neurosurgery, Shimane Prefectural Central Hospital, Izumo, Japan;;Department of Neurosurgery, Graduate School of Biomedical and Health Sciences,;Hiroshima University, Hiroshima, Japan. Electronic address:;fikawa-nsu@umin.ac.jp.;Department of Clinical Epidemiology and Health Economics, School of Public;Health, The University of Tokyo, Tokyo, Japan.;Hiroshima University, Hiroshima, Japan.;Department of Neurosurgery, Tokyo University Hospital, Tokyo, Japan.;Department of Health Policy and Informatics, Tokyo Medical and Dental University;Graduate School of Medicine, Tokyo, Japan.;Department of Neurosurgery, Chugoku Rosai Hospital, Kure, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36356840/ |
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