| アブストラクト | Immunomodulatory drugs (IMIDs) and proteasome inhibitors (PIs) are part of the frontline treatment landscape for multiple myeloma (MM). Despite their effectiveness, these drugs are associated with adverse effects, particularly clinically significant drug-induced peripheral neuropathy. The aim of this study was to evaluate the association between peripheral neuropathy and IMIDs and PIs used in MM, stratified by type of nerve dysfunction. VigiBase, the World Health Organization's global database of individual case safety reports (ICSRs), was analyzed. All ICSRs reported from 1 December 2001 to 31 May 2023 were extracted. Peripheral neuropathy cases were identified using MedDRA-preferred terms (neuropathy peripheral, autonomic neuropathy, peripheral motor neuropathy, peripheral sensory neuropathy) and standardized MedDRA queries (SMQ: peripheral neuropathy). Disproportionality signals were assessed using the reporting odds ratio (ROR) and information component (IC). Associations with peripheral neuropathy were found for all IMIDs and PIs. Both IMIDs and PIs were associated with peripheral sensory neuropathy. Associations with autonomic neuropathy were observed for bortezomib (ROR 12.90; 95% CI: 9.01-18.47), ixazomib (ROR 19.01; 95% CI: 7.89-45.80), carfilzomib (ROR 9.35; 95% CI: 3.01-29.10) thalidomide (ROR 8.86; 95% CI: 4.21-18.70). Associations with peripheral motor neuropathy were detected for bortezomib (ROR 63.87; 95% CI: 51.78-78.80), thalidomide (ROR 30.62; 95% CI: 22.67-41.40), lenalidomide (ROR 2.95; 95% CI: 2.11-4.14), pomalidomide (ROR 5.03; 95% CI: 2.91-8.69). Signals of autonomic neuropathy were identified for bortezomib, carfilzomib, ixazomib, and thalidomide, while signals of peripheral motor neuropathy were observed for bortezomib, thalidomide, lenalidomide, and pomalidomide. Associations with peripheral sensory neuropathy were detected for all IMIDs and PIs analyzed. |
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| ジャーナル名 | Pharmacology research & perspectives |
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| Pubmed追加日 | 2025/12/5 |
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| 投稿者 | Braga, Leticia Penna; de Padua, Cristiane Aparecida Menezes; da Costa, Iwyson Henrique F; de Miranda Drummond, Paula Lana; de Souza, Pedro Henrique Carvalho; Fonseca, Laura Beatriz; Rodrigues, Marina Alacoque; Malta, Jessica Soares; Reis, Adriano Max Moreira |
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| 組織名 | Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte,;Minas Gerais, Brazil.;Hospital Das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte,;Fundacao Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41345994/ |
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