| アブストラクト | The 5-aminosalicylic acid (5-ASA) agents are first-line drugs for ulcerative colitis (UC). However, intolerance as well as other issues have been reported for these drugs, making it difficult to sustain this treatment; accordingly, the persistence of 5-ASA is an important indicator of UC treatment strategy. We aimed to analyze the persistence of 5-ASA in patients with UC in Japan. This was a 1-year, nationwide, population-based cohort study using the National Database of Health Insurance Claims and Specific Health Checkups of Japan. We identified patients who were assigned UC-related disease codes and newly prescribed 5-ASA between April 2015 and September 2019 and specified the number of days until 5-ASA prescriptions were interrupted during a follow-up of up to 365 days. Among the 137 million patients who were covered by the universal health insurance in Japan during the study period, 68,234 eligible patients were identified. The 5-ASA persistence in these patients were 87.2%, 65.6%, and 56.4% after 30, 180, and 365 days, respectively. The 5-ASA persistence by subtype at 365 days was 54.4%, 56.4%, and 57.6% for time-dependent, pH-dependent, and multi-matrix system types, respectively. The 5-ASA persistence rate after 365 days was 65.0% for those under 20 years of age, 51.0% for those 20-39 years old, 57.5% for those 40-64 years old, and 65.5% for those over 64 years of age. This study revealed the 1-year persistence of newly prescribed 5-ASA in patients with UC newly prescribed 5-ASA in Japan, based on a national claims database of more than 100 million individuals. |
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| ジャーナル名 | PloS one |
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| Pubmed追加日 | 2025/1/8 |
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| 投稿者 | Noda, Tatsuya; Kuwaki, Kotaro; Machida, Munehito; Okumura, Yasuyuki; Nishioka, Yuichi; Myojin, Tomoya; Imamura, Tomoaki |
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| 組織名 | Department of Public Health, Health Management and Policy, Nara Medical;University, Nara, Japan.;Department of Public Health, Kurume University School of Medicine, Fukuoka,;Japan.;Division of Gastroenterology, Department of Medicine, Kurume University School of;Medicine, Fukuoka, Japan.;Department of Public Health Policy, National Institute of Public Health, Saitama,;Initiative for Clinical Epidemiological Research, Tokyo, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39775682/ |
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