| アブストラクト | PURPOSE: The purpose of this quantitative comparative study was to examine possible relationship between nicotine replacement therapy (NRT) and cardiac disorder risk by comparing the rates of cardiac disorder risk of NRT with cardiac disorder risk of non-replacement drugs among smokers seeking smoking cessation. METHODS: The study used retrospective quantitative design, which involved collection of secondary data from U.S Food and Drug Administration (FDA)'s adverse event reporting system (FAERS) database. Rates of cardiac disorder were compared between the NRT group and nonNRT (varenicline and bupropion) group. Statistical analyses involved using 2x2 contingency table and logistic regression to calculate odds ratio (reporting odds ratio (ROR)). RESULTS: Unadjusted ROR was 0.45 (95% confidence interval [CI] 0.28, 0.70). With age and sex confounder adjusted, the smokers in NRT group still had lower odds of having cardiac disorder risk than non-NRT group (adjusted ROR=0.44, 95% CI 0.28, 0.70). CONCLUSION: Our study findings showed lower cardiac disorder risk with NRT group compared to non-NRT (varenicline and bupropion) group. While the study was not aimed to undermine either using NRT or non-NRT for smoking cessation therapy to prevent smoking illness, the study results offer informed findings that could potentially improve current smoking cessation management using NRT intervention among smokers and enhance smokers' health outcome. Despite the negative signal detection of cardiac disorder risk with NRT as compared to non-NRT in final findings, we still recommend further research on causal relationship between NRT and nonNRT and cardiac disorder risk. |
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