| アブストラクト | BACKGROUND: Despite the substantial global burden of Clostridioides difficile infection (CDI) and its close relationship with antibiotic exposure, evidence characterizing drug- and age-specific risk patterns remains limited. OBJECTIVES: This study aimed to characterize antibiotic-associated CDI by assessing drug- and age-specific signal patterns and geographic and temporal variations. METHODS: Using the FDA Adverse Event Reporting System (FAERS), antibiotic-associated CDI reports were identified and evaluated through disproportionality analyses (information component [IC] and reporting odds ratio [ROR]). The assessment was then extended to the population level using Global Burden of Disease Study (GBD) 2023 data to evaluate the WHO-regional CDI burden between 1990 and 2023, expressed as disability-adjusted life years (DALYs) and age-standardized DALY rates (ASDRs). RESULTS: Among 23,168,942 FAERS reports, 2,464 antibiotic-associated CDI cases were identified. A strong overall signal was detected (IC, 3.17; ROR, 10.56 [95% CI, 10.11-11.02]). Clindamycin showed the highest individual-level signal (IC, 4.85; ROR, 32.63 [95% CI, 28.76-37.02]), while penicillin combinations, carbapenems, and cephalosporins exhibited the strongest class-level signals. CDI signals peaked among adults aged >/=80 years (ROR, 19.58 [95% CI, 17.73-21.64]). The Region of the Americas recorded the highest CDI burden by 2023, with an ASDR of 10.69 (95% UI, 9.49-12.20) per 100,000 population. CONCLUSIONS: FAERS identified antibiotic- and age-specific CDI reporting signals, while GBD 2023 showed substantial regional heterogeneity in population-level burden. These complementary findings underscore the potential value of clinically contextualized antibiotic stewardship, diagnostic vigilance in vulnerable populations, and region-sensitive CDI surveillance. |
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| ジャーナル名 | International journal of antimicrobial agents |
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| Pubmed追加日 | 2026/9/22 |
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| 投稿者 | Kim, Dain Y; Kim, Hyunjeong; Yoo, Hyunyi; Shin, Hyoin; Yon, Hyunju; Choi, Taelim; Moon, Junmo; Kim, Hyunjee; Lopez-Gil, Jose Francisco; Rahmati, Masoud; Woo, Selin; Park, Jaeyu; Yon, Dong Keon |
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| 組織名 | Center for Digital Health, Medical Science Research Institute, Kyung Hee;University College of Medicine, Seoul, South Korea; Department of Medicine, Korea;University College of Medicine, Seoul, South Korea. Electronic address:;rlaekdls0331@naver.com.;University College of Medicine, Seoul, South Korea; Department of Precision;Medicine, Kyung Hee University College of Medicine, Seoul, South Korea.;Electronic address: hjkim971208@gmail.com.;Electronic address: gusdl619@naver.com.;University College of Medicine, Seoul, South Korea; School of Medicine,;Universidad Espiritu Santo, Samborondon, Ecuador. Electronic address:;hysshin2015@gmail.com.;yhj020202@khu.ac.kr.;Electronic address: 97chlxofla@naver.com.;whyke9242@khu.ac.kr.;Electronic address: niceday1207@naver.com.;School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador;;Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno,;Chile. Electronic address: josefranciscolopezgil@gmail.com.;Health Service Research and Quality of Life Center (CEReSS), Aix-Marseille;University, Marseille, France; Clinical Research Unit, Delegation a la Recherche;Clinique et a l'Innovation du GHT, Centre Hospitalier Intercommunal Toulon La;Seyne sur-Mer, Toulon, France. Electronic address: masoud2_rahmati@yahoo.com.;Electronic address: dntpfls@naver.com.;Electronic address: wodb980@naver.com.;Medicine, Kyung Hee University College of Medicine, Seoul, South Korea;;Department of Medicine, Kyung Hee University College of Medicine, Seoul, South;Korea; Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee;yonkkang@gmail.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42772580/ |
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