| アブストラクト | BACKGROUND: Older adults are at a higher risk of severe adverse drug events (ADEs) because of multimorbidity, polypharmacy, and lower physiological function. This study aimed to determine whether polypharmacy, defined as the use of >/= 5 active drug ingredients, was associated with severe ADEs in this population. METHODS: We used ADE reports from the Korea Institute of Drug Safety and Risk Management-Korea Adverse Event Reporting System Database, a national spontaneous ADE report system, from 2012 to 2021 to examine and compare the strength of association between polypharmacy and severe ADEs in older adults (>/= 65 years) and younger adults (20-64 years) using disproportionality analysis. RESULTS: We found a significant association between severe ADEs of cardiac and renal/urinary Medical Dictionary for Regulatory Activities System Organ Classes (MedDRA SOC) with polypharmacy in older adults. Regarding individual-level ADEs included in these MedDRA SOCs, acute cardiac arrest and renal failure were more significantly associated with polypharmacy in older adults compared with younger adults. CONCLUSION: The addition of new drugs to the regimens of older adults warrants close monitoring of renal and cardiac symptoms. |
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| 投稿者 | Kim, Grace Juyun; Lee, Ji Sung; Jang, Sujung; Lee, Seonghui; Jeon, Seongwoo; Lee, Suehyun; Kim, Ju Han; Lee, Kye Hwa |
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| 組織名 | Big Data Research Center, Asan Institute for Life Sciences, Asan Medical Center,;Seoul, Korea.;Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center,;University of Ulsan College of Medicine, Seoul, Korea.;Department of Biomedical Engineering, Asan Medical Institute of Convergence;Science and Technology, Asan Medical Center, University of Ulsan College of;Medicine, Seoul, Korea.;Healthcare Contents, EVIDNET, Seoul, Korea.;College of Medicine, Chungbuk National University, Cheongju, Korea.;Department of Computer Engineering, Gachon University, Seongnam, Korea.;Division of Biomedical Informatics, Seoul National University, Seoul, Korea.;Department of Information Medicine, Asan Medical Center, Seoul, Korea.;Department of Biomedical Informatics, Ulsan University College of Medicine,;Ulsan, Korea. eva@amc.seoul.kr. |
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