| アブストラクト | Proteasome inhibitors (PIs) are an integral component of multiple myeloma therapies. Peripheral neuropathy (PN) is a well-knownconsequence of PIs, most frequently reported with earlier generations such as bortezomib (BTZ). There is a paucity of data highlighting the risk of developing PN with the new-generation PIs carfilzomib (CFZ) and ixazomib (IZB). This study evaluated reports of PN encountered with all three PIs using the Food and Drug Administration Adverse Event (AE) Reporting System (FAERS). Signal disproportionality analysis was reported using the reporting odds ratio (ROR) with 95% confidence interval (CI). PN was reported in a total of 2.1%, 5.0%, and 10.9% of AEs with CFZ, IZB, and BTZ, respectively. The ROR (95% CI) for PN secondary to BTZ, CFZ, and IZB was 34.10 (32.76-35.49), 6.37 (5.50-7.37), and 14.97 (13.63-16.44), respectively. Compared to BTZ, CFZ and IZB have lower rates of reported PN, with RORs of 0.19 (0.16-0.22) and 0.48 (0.43-0.54), respectively. |
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| ジャーナル名 | Turkish journal of haematology : official journal of Turkish Society of Haematology |
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| 投稿日 | 2021/7/1 |
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| 投稿者 | Mina, Syeda A.; Muhsen, Ibrahim N.; Burns, Ethan A.; Sarfraz, Humaira; Pingali, Sai Ravi; Xu, Jiaqiong; Hashmi, Shahrukh K. |
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| 組織名 | Mayo Clinic, Department of Medicine, Rochester, USA;Houston Methodist Hospital, Department of Medicine, Houston, USA;Houston Methodist Cancer Center, Houston Methodist Hospital, Houston, USA;Center for Outcomes Research, Houston Methodist Research Institute, Houston, USA;Sheikh Shakbout Medical City, Department of Medicine, Abu Dhabi, UAE |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34190655/ |
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