| アブストラクト | OBJECTIVE: A novel COVID-19 therapeutic, nirmatrelvir/ritonavir (Paxlovid), is commonly associated with reports of dysgeusia. The Food and Drug Administration Adverse Event Reporting System (FAERS) database was used to determine the real-world reporting of Paxlovid-associated dysgeusia (PAD), identify associated factors, and describe the relative reporting rates of dysgeusia for Paxlovid compared to other COVID-19 therapeutics (OCT), ritonavir alone, and other protease inhibitors (OPI). STUDY DESIGN: Observational retrospective. SETTING: Tertiary academic medical center. METHODS: We collected patient and adverse event characteristics reported in the FAERS database between January 1968 and September 2022. Disproportionality analyses were used to compare the reporting of PAD to dysgeusia reported for OCT, ritonavir, and OPI. RESULTS: 345,229 adverse events were included in the present study. Dysgeusia was a frequently reported Paxlovid-associated adverse event (17.5%) and was associated with nonserious COVID-19 infection (reporting odds ratio [ROR] 1.4; 95% confidence interval [CI] 1.2, 1.7) and female sex (ROR = 1.7; 95% CI 1.6, 1.9). Paxlovid was more likely to be associated with the reporting of dysgeusia compared to OCT (ROR 305.4; 95% CI 164.1, 568.5), ritonavir (ROR 28.0; 95% CI 24.1, 32.7), and OPI (ROR 49.0; 95% CI 42.8, 56.1). CONCLUSION: Dysgeusia is much more likely to be reported by patients receiving Paxlovid than those receiving OCT, ritonavir alone, or OPI. These findings suggest a potential mechanism of dysgeusia that causes distorted taste out of proportion to the background effects of COVID-19 infection and specific to nirmatrelvir. Future studies are needed to determine the underlying pathophysiology and long-term clinical implications for patients who report dysgeusia with Paxlovid. |
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| ジャーナル名 | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery |
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| 投稿日 | 2023/2/24 |
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| 投稿者 | Cvancara, David J; Baertsch, Hans C; Lehmann, Ashton E; Humphreys, Ian M; Farrell, Nyssa Fox; Marshall, Thomas B; Bhatt, Neel K; Abuzeid, Waleed M; Jafari, Aria |
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| 組織名 | Department of Otolaryngology-Head and Neck Surgery, University of Washington,;Seattle, Washington, USA.;Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine,;University of Southern California, Los Angeles, California, USA.;Department of Otolaryngology-Head and Neck Surgery, Geisinger Medical Center,;Danville, Pennsylvania, USA.;Department of Otolaryngology-Head and Neck Surgery, Washington University in St.;Louis, St. Louis, Missouri, USA.;Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical;School, Norfolk, Virginia, USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/36821807/ |
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