Postpartum Blood Pressure After Hypertensive Disorders of Pregnancy and Subsequent Cardiovascular Disease: A Population-Based Cohort Study.
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アブストラクト OBJECTIVE:To assess the association between blood pressure values at 6 weeks postpartum and subsequent cardiovascular disease (CVD) over a 20-year period among women with hypertensive disorders of pregnancy (HDP).DESIGN:Population-based cohort study.SETTING:English primary and secondary care data, linked to cause-specific mortality records from 2000 to 2020.POPULATION:A cohort of 39 934 women between 15 and 49 years of age at birth who had HDP, were registered with a general practitioner (GP) contributing to the Clinical Practice Research Datalink (CPRD), and eligible for linkage to hospital episode statistics (HES) data were included. We excluded 22 100 (55.3%) women with no blood pressure values recorded at 6 weeks postpartum.METHODS:Primary analysis included multivariable Cox regression modelling (weighted by the inverse probability of having a severe HDP).MAIN OUTCOME MEASURE:Validated composite outcome of 12 cardiovascular diseases.RESULTS:The rate for incident cardiovascular events was 109 per 10 000 person-years; 794 (68%) of them occurred in women aged < 40 years. Women with abnormal blood pressure at 6 weeks postpartum had a higher risk of subsequent CVD than women with normal blood pressure: 10.9% vs. 5.4% - adjusted hazard ratio 1.96 (95% CI 1.51-2.54).CONCLUSIONS:Less than half of women with HDP had a blood pressure record in their GP notes at 6 weeks postpartum. The absence of a record of normal blood pressure at this time point was associated with an increased risk for subsequent CVD The immediate postpartum period may be a crucial window in preventive care to improve women's health.ジャーナル名 BJOG : an international journal of obstetrics and gynaecology Pubmed追加日 2026/10/17 投稿者 Korb, Diane; Ramakrishnan, Rema; Kwok, Aden C H; Li, Yangmei; Carson, Claire; Knight, Marian 組織名 National Perinatal Epidemiology Unit, Nuffield Department of Women's and;Reproductive e Health, University of Oxford, New Radcliffe House, Oxford, UK.;Universite de Paris, CRESS, Obstetrical Perinatal and Pediatric Epidemiology;Research Team, EPOPe, INSERM, INRAE, Paris, France.;Service de Gynecologie Obstetrique, Hopital Robert Debre, Assistance;Publique-Hopitaux de Paris, Universite Paris Cite, Paris, France.;Big Data Institute, Li Ka Shing Centre for Health Information and Discovery,;University of Oxford, Oxford, UK.;Nuffield Department of Population Health, University of Oxford, Oxford, UK. Pubmed リンク https://www.ncbi.nlm.nih.gov/pubmed/42888852/ -
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