| アブストラクト | The aim of this study was to analyze the potential adverse events (AEs) caused by Janus kinase (JAK) inhibitors, including tofacitinib, baricitinib, and upadacitinib, used to treat rheumatoid arthritis using spontaneous AE reports from the FDA (FAERS) and interpreting them in correlation with those from Korea (KAERS) and an online patient review (WebMD). Potential AEs were identified based on a disproportionality analysis using the proportional reporting ratio (PRR), reporting odds ratio (ROR), and the information component (IC). A total of 23,720 reports were analyzed from FAERS database, of which 91.5% were reports on tofacitinib. Potentially important medical AEs related to infections were reported frequently, as well as thromboembolism-related AEs. The AEs, such as malignancy, interstitial lung diseases, myocardial infarction, and gastrointestinal disorder, also reported. In an online patient review report, the ineffectiveness of the drug and gastrointestinal AEs were frequently reported. Infection with baricitinib and symptoms related to pain or edema due to upadacitinib were the main discomfort experienced by patients. In conclusion, the results of this study highlight the possible safety issues associated with JAK inhibitors. Routine clinical observations and further research using various real-world databases are needed. |
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| 投稿日 | 2022/1/29 |
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| 投稿者 | Song, Yun-Kyoung; Song, Junu; Kim, Kyungim; Kwon, Jin-Won |
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| ジャーナル名 | Frontiers in pharmacology |
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| 組織名 | College of Pharmacy, Daegu Catholic University, Gyeongsan, South Korea.;Department of Computer Science, Viterbi School of Engineering, University of;Southern California, Los Angeles, CA, United States.;College of Pharmacy, Korea University, Sejong, South Korea.;Institute of Pharmaceutical Science, Korea University, Sejong, South Korea.;BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit,;College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook;National University, Daegu, South Korea. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35087406/ |
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