| アブストラクト | OBJECTIVES: To develop and validate a clinical risk score to identify patients at risk of chronic obstructive pulmonary disease (COPD) using clinical factors routinely recorded in primary care. DESIGN: Case-control study of patients containing one incident COPD case to two controls matched on age, sex and general practice. Candidate risk factors were included in a conditional logistic regression model to produce a clinical score. Accuracy of the score was estimated on a separate external validation sample derived from 20 purposively selected practices. SETTING: UK general practices enrolled in the Clinical Practice Research Datalink (1 January 2000 to 31 March 2006). PARTICIPANTS: Development sample included 340 practices containing 15 159 newly diagnosed COPD cases and 28 296 controls (mean age 70 years, 52% male). Validation sample included 2259 cases and 4196 controls (mean age 70 years, 50% male). MAIN OUTCOME MEASURES: Area under the receiver operator characteristic curve (c statistic), sensitivity and specificity in the validation practices. RESULTS: The model included four variables including smoking status, history of asthma, and lower respiratory tract infections and prescription of salbutamol in the previous 3 years. It had a high average c statistic of 0.85 (95% CI 0.83 to 0.86) and yielded a sensitivity of 63.2% (95% CI 63.1 to 63.3) and specificity 87.4% (95% CI 87.3 to 87.5). CONCLUSIONS: Risk factors associated with COPD and routinely recorded in primary care have been used to develop and externally validate a new COPD risk score. This could be used to target patients for case finding. |
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| ジャーナル名 | BMJ open respiratory research |
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| Pubmed追加日 | 2015/4/9 |
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| 投稿者 | Haroon, Shamil; Adab, Peymane; Riley, Richard D; Marshall, Tom; Lancashire, Robert; Jordan, Rachel E |
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| 組織名 | Department of Public Health, Epidemiology & Biostatistics , School of Health and;Population Sciences, College of Medical and Dental Sciences, University of;Birmingham , Birmingham , UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25852945/ |
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