| アブストラクト | PURPOSE: Self-harm is a public health problem that requires a better understanding of mortality risk. We undertook a study to examine premature mortality in a nationally representative cohort of primary care patients who had harmed themselves. METHODS: During 2001-2013, a total of 385 general practices in England contributed data to the Clinical Practice Research Datalink with linkage to Office for National Statistics mortality records. We identified 30,017 persons aged 15 to 64 years with a recorded episode of self-harm. We estimated the relative risks of all-cause and cause-specific natural and unnatural mortality using a comparison cohort of 600,258 individuals matched on age, sex, and general practice. RESULTS: We found an elevated risk of dying prematurely from any cause among the self-harm cohort, especially in the first year of follow-up (adjusted hazard ratio for that year, 3.6; 95% CI, 3.1-4.2). In particular, suicide risk was especially high during the first year (adjusted hazard ratio, 54.4; 95% CI, 34.3-86.3); although it declined sharply, it remained much higher than that in the comparison cohort. Large elevations of risk throughout the follow-up period were also observed for accidental, alcohol-related, and drug poisoning deaths. At 10 years of follow-up, cumulative incidence values were 6.5% (95% CI, 6.0%-7.1%) for all-cause mortality and 1.3% (95% CI, 1.2%-1.5%) for suicide. CONCLUSIONS: Primary care patients who have harmed themselves are at greatly increased risk of dying prematurely by natural and unnatural causes, and especially within a year of a first episode. These individuals visit clinicians at a relatively high frequency, which presents a clear opportunity for preventive action. Primary care patients with myriad comorbidities, including self-harming behavior, mental disorder, addictions, and physical illnesses, will require concerted, multipronged, multidisciplinary collaborative care approaches. |
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| ジャーナル名 | Annals of family medicine |
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| 投稿日 | 2017/5/10 |
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| 投稿者 | Carr, Matthew J; Ashcroft, Darren M; Kontopantelis, Evangelos; While, David; Awenat, Yvonne; Cooper, Jayne; Chew-Graham, Carolyn; Kapur, Nav; Webb, Roger T |
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| 組織名 | Division of Psychology and Mental Health, Faculty of Biology, Medicine and;Health, University of Manchester, Manchester Academic Health Science Centre,;Manchester M13 9PL, UK (Carr, While, Awenat, Cooper, Kapur, Webb); Division of;Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of;Manchester, Manchester Academic Health Science Centre, Manchester M13 9PL, UK;(Ashcroft); NIHR Greater Manchester Primary Care Patient Safety Translational;Research Centre, Manchester M13 9PL, UK (Ashcroft); Division of Informatics,;Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of;(Kontopantelis); Research Institute of Primary Care and Health Sciences, Keele;University, Staffordshire ST5 5BG, UK (Chew-Graham); West Midlands NIHR;Collaborative Leadership in Applied Health Research and Care (CLAHRC),;Birmingham, UK (Chew-Graham). matthew.carr@manchester.ac.uk.;Birmingham, UK (Chew-Graham). |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28483890/ |
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