| アブストラクト | Introduction: Traditional Japanese (Kampo) medicines are often prescribed for women in Japan before, during, and after pregnancy. However, detailed information on the actual frequency of use and safety of Kampo preparations during pregnancy is lacking. Aim: To investigate the frequency of prescription of Kampo medicines for pregnant women in Japan. Methods: Information on Kampo medicines prescribed during outpatient care and hospitalization of selected mothers from January 2005 to August 2016 were extracted from the Japan Medical Data Center (Tokyo, Japan), which is a large claims database. Results: Of the 33,941 subscribers identified from the database, 16,294 (48%) received at least one prescription of a Kampo medicine. Kakkonto was the formula most prescribed during the study period, followed by shoseiryuto and tokishakuyakusan. In the 180 days before pregnancy, the most prescribed medicine was tokishakuyakusan, followed by kakkonto and shoseiryuto. Shoseiryuto, tokishakuyakusan, and kakkonnto were the formulae most prescribed during pregnancy. The most prescribed medicines during the 180 days postpartum were kakkonto, shoseiryuto, and saireito. Conclusions: Information in the Japanese insurance system shows that Kampo medicines are often prescribed during pregnancy. Most of these prescriptions are generally used for the treatment of common cold. Tokishakuyakusan in particular is usually used in the treatment of various symptoms of pregnancy. Further research is needed to clarify the relationship between the use of Kampo medicines during pregnancy and adverse events in infants in Japan. |
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| ジャーナル名 | Frontiers in nutrition |
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| 投稿日 | 2021/12/7 |
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| 投稿者 | Suzuki, Satoko; Obara, Taku; Ishikawa, Tomofumi; Noda, Aoi; Matsuzaki, Fumiko; Arita, Ryutaro; Ohsawa, Minoru; Mano, Nariyasu; Kikuchi, Akiko; Takayama, Shin; Ishii, Tadashi |
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| 組織名 | Department of Education and Support for Regional Medicine, Tohoku University;Hospital, Sendai, Japan.;Department of Kampo Medicine, Tohoku University Hospital, Sendai, Japan.;Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.;Division of Molecular Epidemiology, Department of Preventive Medicine and;Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai,;Japan.;Laboratory of Clinical Pharmacy, Tohoku University Graduate School of;Pharmaceutical Sciences, Sendai, Japan.;Department of Obstetrics and Gynecology, Tohoku University Hospital, Sendai, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34869533/ |
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