| アブストラクト | INTRODUCTION: Parkinson's disease (PD) treatment should follow guidelines and be tailored to each patient. Large database analyses can provide insights into prescribing patterns. METHODS: Retrospective, cross-sectional study of patients (>/=30 years) with PD diagnosis (ICD-10; schizophrenia/cerebrovascular disease excluded) using health insurance claims data (April 2008-December 2016) from the Japan Medical Data Vision database. Prescription patterns of anti-PD drugs were analysed by patient age and sex, calendar year, and overall. RESULTS: The analysis comprised 155,493 PD patient-years (56.1% women, mean 73.4 years). Patient number increased each year, mainly because of database expansion. L-dopa as monotherapy was the most common prescription (22.7% of patient-years); non-ergot dopamine agonists (DAs) were also common (7.6% as monotherapy, 6.8% with L-dopa). Monotherapy was prescribed for ~50% of patient-years, two drugs for 14.1%, and at least three drugs for 18.4%. Consistent with Japanese guidelines, L-dopa was mostly prescribed to older patients (>/=60 years), whereas non-ergot DAs were mostly prescribed to middle-aged patients (peak at 50-69 years). Between 2008 and 2011, L-dopa prescription decreased while that of non-ergot DAs increased; this pattern reversed between 2012 and 2016. CONCLUSION: These results indicate that Japanese clinicians are adhering to Japanese guidelines and tailoring anti-PD treatment to individual patients. |
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| 投稿日 | 2020/8/11 |
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| 投稿者 | Suzuki, Masahiko; Arai, Masaki; Hayashi, Ayako; Ogino, Mieko |
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| ジャーナル名 | eNeurologicalSci |
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| 組織名 | Department of Neurology, The Jikei University Katsushika Medical Center, Tokyo,;Japan.;Japan Medical Affairs, Takeda Pharmaceutical Company Limited, Tokyo, Japan.;International University of Health and Welfare, School of Medicine, Center for;Medical Education, Narita, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/32775705/ |
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