| アブストラクト | PURPOSE: To retrospectively investigate the prevalence, demography, antiseizure medication (ASM) usage, healthcare resource utilization (HCRU), and mortality of patients with Lennox-Gastaut syndrome (LGS) in primary and secondary care in the UK. METHODS: Patients with confirmed LGS were anonymously identified from the UK Clinical Practice Research Datalink (CPRD) GOLD database (01/01/1987-31/1b0/2018) using the LGS Read Code (F250500). Probable LGS was identified using the International Classification of Diseases-10/Read Code for epilepsy (Hospital Episode Statistics [HES]/CPRD) plus rufinamide prescription. Period prevalence was calculated based on patients enrolled in CPRD GOLD and alive in 2017. CPRD data were linked to HES to calculate HCRU, and to the Office for National Statistics mortality registry. RESULTS: Period prevalence of LGS was 0.578/10,000 (n = 180), with 74 and 106 patients identified with confirmed (0.289/10,000) and probable LGS (0.420/10,000). Mean (max) ASM usage was ~1 (3) per year. In confirmed LGS, valproate (72%), lamotrigine (69%), and clobazam (66%) were the most commonly prescribed ASMs. HCRU (per patient-year) was similar in confirmed and probable LGS and mostly consisted of primary care general practitioner consultations (4-6), outpatient visits (5-10), inpatient admissions (1-4), and A&E visits (1). During the follow-up period, 18 patients died with crude mortality rates of 6.12 (confirmed LGS) and 4.17 (probable LGS) deaths per 1000 person-years. CONCLUSION: Prevalence of LGS appears low in the UK. The similarly high HCRU and mortality rates in confirmed and probable LGS support the validity and specificity of the probable LGS algorithm and high burden of LGS. |
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| 組織名 | Muir Maxwell Epilepsy Centre, Child Life and Health, University of Edinburgh,;Royal Hospital for Children and Young People, 50 Little France Crescent,;Edinburgh BioQuarter, Edinburgh, EH16 4TJ, UK. Electronic address:;rchin@exseed.ed.ac.uk.;Neurology and Molecular Neuroscience Group, Institute of Life Science, Swansea;University Medical School, Swansea University, Swansea, SA2 8PP, UK; Neurology;Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6;6NL, UK. Electronic address: w.o.pickrell@swansea.ac.uk.;Value, Access & HEOR, Commercial Advisory Group, Syneos Health, 41/45 Boulevard;Romain Rolland, 92120 Montrouge, Paris, France. Electronic address:;florent.guelfucci@syneoshealth.com.;Evidence Synthesis, Modeling, Communications, Evidera, The Ark, 201 Talgarth;Road, London W6 8BJ, UK. Electronic address: martinmoniq@googlemail.com.;Market Access and Health Economics and Outcomes Research, GW Pharma Ltd, 1;Cavendish Pl, Marylebone, London W1G 0QF, UK. Electronic address:;RHolland@gwpharm.com. |
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