| アブストラクト | OBJECTIVE: To analyse pristinamycin/vitamin K antagonists (VKA) drug interaction by using data recorded in the French pharmacovigilance database (FPVB). METHODS: All cases with an increase effect of a VKA and an association with pristinamycin recorded in the FPVB between 1985 and 2013 were included. Data concerning patients, VKA treatments and side effects were recorded for a descriptive analysis. RESULTS: During this period, 31 reports with a VKA overdose after an association with pristinamycin were included. Fluindione is the most often involved VKA (77% of cases). In 20 cases (65.4%), VKA overdose caused bleeding and 24 cases (77.4%) were serious. CONCLUSION: Although mechanism is unknown, pristinamycine/AVK drug interaction is a reality that needs to be reported in the summary of product characteristics of these drugs and better known by practitioners to act in patients' interest. |
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| ジャーナル名 | Therapie |
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| 投稿日 | 2014/7/23 |
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| 投稿者 | Guiboux, Anne-Laure; Dautriche, Anne; Rocher, Fanny; Bruel, Mery; Sgro, Catherine |
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| 組織名 | Centre regional de Pharmacovigilance de Bourgogne, Centre hospitalier;universitaire de Dijon, Dijon, France.;Centre regional de Pharmacovigilance de Nice, Hopital de Cimiez, Nice, France.;Centre regional de Pharmacovigilance de Lyon, Hospices civils de Lyon, Lyon,;France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25047671/ |
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