| アブストラクト | OBJECTIVES: To assess whether prodromal symptoms of RA, as recorded in the Clinical Practice Research Datalink Aurum (CPRD) database of English primary care records, differ by ethnicity and socioeconomic status. METHODS: A cross-sectional study to determine the coding of common symptoms (>/=0.1% in the sample) in the 24 months preceding RA diagnosis in CPRD Aurum, recorded between 1 January 2004 and 1 May 2022. Eligible cases were adults with a code for RA diagnosis. For each symptom, a logistic regression was performed with the symptom as dependent variable, and ethnicity and socioeconomic status as independent variables. Results were adjusted for sex, age, BMI and smoking status. White ethnicity and the highest socioeconomic quintile were comparators. RESULTS: In total, 70 115 cases were eligible for inclusion, of which 66.4% were female. Twenty-one symptoms were coded in >0.1% of cases so were included in the analysis. Patients of South Asian ethnicity had higher frequency of codes for several symptoms, with the largest difference by odds ratio being muscle cramps (1.71, 99.76 % confidence interval 1.44-2.57) and shoulder pain (1.44, 1.25-1.66). Patients of Black ethnicity had higher prevalence of several codes including unintended weight loss (2.02, 1.25-3.28) and ankle pain (1.51, 1.02-2.23). Low socioeconomic status was associated with morning stiffness (1.74, 1.08-2.80) and falls (1.37, 2.03-1.82). CONCLUSION: There are significant differences in coded symptoms between demographic groups, which must be considered in clinical practice in diverse populations and to avoid algorithmic bias in prediction tools derived from routinely collected healthcare data. |
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| ジャーナル名 | Rheumatology (Oxford, England) |
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| Pubmed追加日 | 2024/3/11 |
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| 投稿者 | d'Elia, Alexander; Baranskaya, Aliaksandra; Haroon, Shamil; Hammond, Ben; Adderley, Nicola J; Nirantharakumar, Krishnarajah; Chandan, Joht Singh; Falahee, Marie; Raza, Karim |
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| 組織名 | Department of Public Health Policy and Systems, Institute of Population Health,;University of Liverpool, Liverpool, UK.;Rheumatology Research Group, Institute of Inflammation and Ageing, University of;Birmingham, Birmingham, UK.;Institute of Applied Health Research, University of Birmingham, Birmingham, UK.;NIHR Birmingham Biomedical Research Centre, University Hospitals Birmingham NHS;Foundation Trust, Birmingham, UK.;Department of Rheumatology, Bronglais Hospital, Hywel Dda University Health;Board, Aberystwyth, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38466930/ |
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