| アブストラクト | BACKGROUND AND OBJECTIVE: Intellectual disability (ID) is increasingly recognised as a hidden driver of cancer mortality. However, evidence on prostate cancer (PC) care in this population is limited. METHODS: The study population comprised 29 554 men with an ID and 518 739 comparators from the Clinical Practice Research Datalink Aurum database, which is linked to hospital, mortality, and cancer registry data. Poisson and Cox regression analyses were used to estimate incidence rate ratios (IRRs), risk ratios (RRs), and hazard ratios (HRs) with 95% confidence intervals (CIs) for outcomes related to PC presentation, diagnosis, treatment, and survival. KEY FINDINGS AND LIMITATIONS: The ID group presented more frequently with symptoms suggestive of PC (IRR 1.35, 95% CI 1.28-1.43) but were less likely to have a prostate-specific antigen (PSA) test within 90 d (RR 0.66, 95% CI 0.63-0.70). Following detection of elevated PSA, the ID group had fewer referrals (RR 0.83, 95% CI 0.72-0.96), biopsies (RR 0.54, 95% CI 0.41-0.71), and PC diagnoses (RR 0.51, 95% CI 0.41-0.65). The ID group were also more likely to be diagnosed on the date of death (RR 5.96, 95% CI 2.70-11.77), have missing Gleason scores (RR 1.61, 95% CI 1.27-2.01), and present with de novo metastatic PC (RR 1.79, 95% CI 1.15-2.77). Among those with Gleason scores, the rate of clinically significant PC (Gleason >/=7) was comparable between the ID and control groups, while receipt of radical treatment for nonmetastatic PC was slightly lower in the ID group (RR 0.73, 95% CI 0.51-1.00). Men with an ID had twofold higher risk of death from PC following diagnosis (HR 2.11, 95% CI 1.64-2.73). CONCLUSIONS AND CLINICAL IMPLICATIONS: Men with an ID face disparities across the PC care pathway from investigation of relevant symptoms to survival after diagnosis. Targeted interventions are needed to address these inequities. |
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| ジャーナル名 | European urology oncology |
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| Pubmed追加日 | 2026/2/21 |
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| 投稿者 | Kennedy, Oliver John; Chauhan, Umesh; Gorman, Louise; Lorigan, Paul; Merriel, Samuel W D; Staa, Tjeerd Van; Wright, Alison; Ashcroft, Darren Mark |
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| 組織名 | Division of Cancer Sciences, University of Manchester, Manchester, UK; The;Christie NHS Foundation Trust, Manchester, UK. Electronic address:;oliver.kennedy@manchester.ac.uk.;School of Medicine, University of Lancashire, Preston, UK.;NIHR Greater Manchester Patient Safety Research Collaboration, University of;Manchester, Manchester, UK.;Christie NHS Foundation Trust, Manchester, UK.;Centre for Primary Care and Health Services Research, University of Manchester,;Manchester, UK.;Centre for Pharmacoepidemiology and Drug Safety, University of Manchester,;Manchester, UK; Manchester Academic Health Science Centre, Manchester, UK.;Manchester, Manchester, UK; Centre for Pharmacoepidemiology and Drug Safety,;University of Manchester, Manchester, UK; Manchester Academic Health Science;Centre, Manchester, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/41720694/ |
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