| アブストラクト | OBJECTIVE: Evidence for an association between psoriasis and dementia is limited and conflicting. We aimed to investigate the association using large and representative population-based data and describe risk by dementia subtype and over time. METHODS: We compared dementia risk between people with and without psoriasis using an age-, sex- and primary care practice-matched cohort of adults aged >/=40 years from the Clinical Practice Research Datalink Aurum in England (1997-2021) linked to hospital admissions data, analysed with stratified Cox regression. RESULTS: Among 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all-cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04-1.08; absolute rate difference 24 per 100,000 person-years). Strength of association increased with time since psoriasis diagnosis (e.g. aHR 0.99, 0.96-1.03 within 0 to 5 years; 1.20, 1.05-1.37 within 20 to 25 years). The association was stronger for vascular dementia (aHR 1.10, 1.06-1.14) than Alzheimer's dementia (aHR 1.03, 1.00-1.06). Hazard ratios were larger for severe psoriasis (all-cause aHR 1.32, 1.25-1.39; vascular aHR 1.58, 1.44-1.74; Alzheimer's aHR 1.11, 1.02-1.21). INTERPRETATION: Long-term risk of all-cause dementia and vascular dementia, but not Alzheimer's dementia, was slightly higher in people with psoriasis, but absolute risk differences were small. Risks were more substantially raised with time since psoriasis diagnosis and in severe psoriasis compared to mild to moderate psoriasis, suggesting a potential dose-response relationship. |
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| ジャーナル名 | Annals of clinical and translational neurology |
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| Pubmed追加日 | 2025/1/2 |
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| 投稿者 | Matthewman, Julian; Mansfield, Kathryn E; Cadogan, Sharon L; Abuabara, Katrina; Smith, Catherine; Bhaskaran, Krishnan; Langan, Sinead M; Warren-Gash, Charlotte |
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| 組織名 | Department of Non-Communicable Disease Epidemiology, London School of Hygiene and;Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.;Department of Dermatology, University of California San Francisco, 1701;Divisadero Street, San Francisco, California, 94115, USA.;King's College London, St John's Institute of Dermatology, 2 Lambeth Palace Rd,;London, SE1 7EP, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39743756/ |
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