| アブストラクト | The association between psoriasis and risk of major cardiovascular (CV) events (myocardial infarction, acute coronary syndrome, unstable angina, and stroke) is unclear. A cohort study with 48,523 patients with psoriasis and 208,187 controls was conducted. During a median follow-up of 5.2 years, 1,257 patients with psoriasis (2.59%) had a major CV event, compared with 4,784 controls (2.30%). In the multivariable analysis, inflammatory arthritis hazard ratio (HR) 1.36 (1.18-1.58), diabetes HR 1.18 (1.06-1.31), chronic kidney disease HR 1.18 (1.07-1.31), hypertension HR 1.37 (1.29-1.45), transient ischemic attack HR 2.74 (2.41-3.12), atrial fibrillation HR 1.54 (1.36-1.73), valvular heart disease HR 1.23 (1.05-1.44), thromboembolism 1.32 (1.17-1.49), congestive heart failure HR 1.57 (1.39-1.78), depression HR 1.16 (1.01-1.34), current smoker HR 2.18 (2.03-2.33), age (year) HR 1.07 (1.07-1.07), and male gender HR 1.83 (1.69-1.98) were statistically significant for the risk of major CV events. The age- and gender-adjusted HRs of a major CV event for psoriasis were 1.10 (1.04-1.17) and for severe psoriasis 1.40 (1.07-1.84), whereas the fully adjusted HRs were attenuated to 1.02 (0.95-1.08) and 1.28 (0.96-1.69). In conclusion, neither psoriasis nor severe psoriasis were associated with the short-to-medium term (over 3-5 years) risk of major CV events after adjusting for known cardiovascular disease risk factors. |
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| ジャーナル名 | The Journal of investigative dermatology |
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| 投稿日 | 2015/3/6 |
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| 投稿者 | Parisi, Rosa; Rutter, Martin K; Lunt, Mark; Young, Helen S; Symmons, Deborah P M; Griffiths, Christopher E M; Ashcroft, Darren M |
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| 組織名 | Centre for Pharmacoepidemiology & Drug Safety, Manchester Pharmacy School,;University of Manchester, Manchester, UK.;Manchester Diabetes Centre, Central Manchester University Hospitals NHS;Foundation Trust, Manchester Academic Health Science Centre, University of;Manchester, Manchester, UK; Endocrinology and Diabetes Research Group, Institute;of Human Development, University of Manchester, Manchester, UK.;Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal;Research, Institute of Inflammation and Repair, University of Manchester,;Manchester, UK.;The Dermatology Research Centre, Salford Royal Hospital, Institute of;Inflammation and Repair, University of Manchester, Manchester, UK.;Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit,;Manchester Academic Health Science Centre, University of Manchester, Manchester,;UK.;University of Manchester, Manchester, UK. Electronic address:;darren.ashcroft@manchester.ac.uk. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/25742120/ |
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