| アブストラクト | INTRODUCTION: Immunoassay urine drug screen (UDS) is frequently used in clinical practice for initial screening process, being generally available, fast, and inexpensive. Exposure to widely prescribed drugs might determine false-positive UDS amphetamines, leading to diagnostic issues, wrong therapeutic choices, impairment of physician-patient relationship, and legal implications. AREAS COVERED: To summarize and comment on a comprehensive list of compounds responsible for UDS false positives for amphetamines, we conducted a literature review on PubMed along with a comparison with Real-World Data from the Food and Drug Administration Adverse Event Reporting System (FAERS) database analysis between 2010 and 2022. Forty-four articles and 125 Individual Case Safety Reports (ICSR) involving false-positive amphetamine UDS in psychiatric patients were retrieved from FAERS. EXPERT OPINION: False-positive results were described in literature for antidepressants, atomoxetine, methylphenidate, and antipsychotics, but also for non-psychiatric drugs of common use, such as labetalol, fenofibrate, and metformin. Immunoassay method is usually responsible for false-positive results, and in most cases, mass spectrometry (MS) does not eventually confirm the UDS positivity. Physicians should be aware of immunoassays' limitations and when turning to a confirmatory test. Any new cross-reaction should be reported to pharmacovigilance activities. |
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| ジャーナル名 | Expert review of clinical pharmacology |
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| Pubmed追加日 | 2023/5/6 |
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| 投稿者 | Battini, Vera; Cirnigliaro, Giovanna; Giacovelli, Luca; Boscacci, Maria; Massara Manzo, Silvia; Mosini, Giulia; Guarnieri, Greta; Gringeri, Michele; Benatti, Beatrice; Clementi, Emilio; Dell'Osso, Bernardo; Carnovale, Carla |
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| 組織名 | Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences,;"Luigi Sacco" University Hospital, Universita di Milano, Milan, Italy.;Department of Biomedical and Clinical Sciences, Department of Psychiatry, ASST;Fatebenefratelli-Sacco, University of Milan, Milan, Italy.;IRCCS Stella Maris Foundation, Scientific Institute of Child Neurology and;Psychiatry, Calambrone, Pisa, Italy.;Department of Clinical and Experimental Medicine, University of Pisa, Pisa,;Italy.;"Aldo Ravelli" Center for Nanotechnology and Neurostimulation, University of;Milan, Milan, Italy.;Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy.;Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford,;CA, USA.;"Centro per lo studio dei meccanismi molecolari alla base delle patologie;neuro-psico-geriatriche", University of Milan, Milan, Italy. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37147189/ |
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