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Pulmonary hypertension reported with immune checkpoint inhibitors: a pharmacovigilance study.

• アブストラクト	Immune checkpoint inhibitors (ICI) restore immune response against cancer cells that can lead to immune-related adverse effects. While cardiovascular immune-related adverse effects are known to be associated with checkpoint inhibitors, recent case reports have raised concerns about the potential association with pulmonary hypertension (PH). By using the global pharmacovigilance database VigiBase, we investigated the onset of PH associated with ICI and propose a comprehensive description of the 42 cases of PH reported with ICI recorded in this database. Through this study and review of the cases published in the literature, we discuss the possible link between PH and ICI in the context of cancer in order to better understand this rare but potentially fatal event.
  ジャーナル名	Cancer immunology, immunotherapy : CII
  投稿日	2022/5/27
  投稿者	Palassin, Pascale; Maria, Alexandre T J; Ladhari, Chayma; Quantin, Xavier; Montani, David; Bourdin, Arnaud; Boissin, Clement; Fesler, Pierre; Hillaire-Buys, Dominique; Guilpain, Philippe; Faillie, Jean-Luc
  組織名	Department of Medical Pharmacology and Toxicology, Montpellier, University;Hospital, Montpellier, France.;Department of Internal Medicine-Multi-Organic Diseases, Local Referral Center for;Rare Auto-Immune Diseases, Saint Eloi Hospital, Montpellier University Hospital,;Montpellier, France.;Univ Montpellier, IRMB, Montpellier, France.;Department of Medical Oncology, Thoracic Oncology, Montpellier Cancer Institute,;Univ Montpellier, Montpellier, France.;Universite Paris-Saclay, School of Medicine, Le Kremlin-Bicetre, France.;INSERM UMR_S 999, Hopital Marie Lannelongue, Le Plessis-Robinson, France.;AP-HP, Department of Respiratory and Intensive Care Medicine, Hopital Bicetre, Le;Kremlin-Bicetre, France.;Department of Respiratory Diseases, University of Montpellier, CHU Montpellier,;PhyMedExp, INSERM U1046, CNRS UMR 9214, University of Montpellier, Montpellier,;France.;Department of Internal Medicine and Arterial Hypertension, Lapeyronie Hospital,;Montpellier University Hospital, Montpellier, France.;Hospital, Montpellier, France. jl-faillie@chu-montpellier.fr.;IDESP, Univ Montpellier, INSERM, Montpellier, France.;jl-faillie@chu-montpellier.fr.
  Pubmed リンク	https://www.ncbi.nlm.nih.gov/pubmed/35616698/

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