| アブストラクト | No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-TNF-alpha treatment has been recently reported. Very recently 70 cases of tuberculosis were reported from the FDA Adverse Event Reporting System. We report a case of pulmonary miliary tuberculosis in a RA patient treated with TNF-alpha blockade. The important role of TNF-alpha in defence against tuberculosis and possible mechanisms of anti-TNF-alpha agents impairing tuberculosis immune response are discussed. |
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| ジャーナル名 | Scandinavian journal of rheumatology |
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| Pubmed追加日 | 2002/4/2 |
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| 投稿者 | Mayordomo, Lucia; Marenco, Jose Luis; Gomez-Mateos, Jesus; Rejon, Eduardo |
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| 組織名 | Rheumatology Unit, Hospital Universitario Valme, Seville, Spain.;lmayordomo@wanadoo.es |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/11922200/ |
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