| アブストラクト | INTRODUCTION: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice. MATERIAL AND METHODS: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls. RESULTS: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with >/=70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to <30%). CONCLUSIONS: Higher time spent within therapeutic INR range was associated with lower risks of VTE recurrence and death due to VTE. |
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| ジャーナル名 | Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
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| 投稿日 | 2012/01/26 |
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| 投稿者 | Gallagher, Arlene M; de Vries, Frank; Plumb, Jonathan M; Hass, Bastian; Clemens, Andreas; van Staa, Tjeerd-Pieter |
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| 組織名 | General Practice Research Database, Medicines and Healthcare products Regulatory;Agency, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/22275390/ |
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