| アブストラクト | BACKGROUND: Dry eye syndrome (DES) significantly affects quality of life. Meibomian Gland Dysfunction (MGD) is a primary contributor to DES and may be drug-induced. RESEARCH DESIGN AND METHODS: This study analyzed data from the FDA Adverse Event Reporting System (FAERS) between January 2004 and September 2023 using the Ratio of Odds Ratios (ROR) and Proportional Reporting Ratio (PRR) to detect potential drug-induced MGD signals. Drugs were categorized by therapeutic class. RESULTS: Among 289 MGD cases, the average patient age was 51.69 years, with 65.44% female. MGD reports have increased over time, peaking in 2023, primarily from the United States and Europe. Of 148 drugs, nine showed significant associations with MGD, including those in ophthalmology, oncology, immunomodulation, dermatology, and the urogenital system. CONCLUSION: This real-world study identifies drugs potentially linked to MGD, offering valuable insights for drug safety surveillance. These findings support the development of pharmacovigilance strategies and optimized clinical practice to mitigate ocular risks. |
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| 投稿者 | Li, Xiang; Wu, Shi-Nan; Zhang, Si-Qi; Zhang, Zhi-Jie; Wang, Meng-Yuan; Chen, Cui-Ting; Luo, Zhan-Yang; Dong, Nuo |
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| 組織名 | Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen;University, Xiamen, Fujian, China.;Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of;Medicine, Xiamen University, Xiamen, Fujian, China.;Huaxia Eye Hospital of Quanzhou, Quanzhou, Fujian, China.;Department of Oncology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian,;China.;Department of Pharmacy, Shanghai Pudong Hospital, Fudan University Pudong Medical;Center, Shanghai, China.;Xiamen Clinical Research Center for Eye Diseases, Xiamen, Fujian, China.;Xiamen Key Laboratory of Ophthalmology, Xiamen, Fujian, China.;Fujian Provincial Key Laboratory of Ocular Surface and Corneal Disease, Xiamen,;Fujian, China.;Xiamen Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian,;Translational Medicine Institute of Xiamen Eye Center of Xiamen University,;Xiamen, Fujian, China.;Department of Ophthalmology, Affiliated people's hospital, Zhenjiang kangfu eye;hospital, Zhenjiang College, Zhenjiang, Jiangsu, China. |
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