| アブストラクト | OBJECTIVES: To characterise the real-world burden of chronic rhinosinusitis with nasal polyps (CRSwNP) in the UK, stratified by number of surgeries. DESIGN: Retrospective cohort study. SETTING: UK Clinical Practice Research Datalink Aurum database with Hospital Episodes Statistics linkage (2007-2019). PARTICIPANTS: Adults >/=18 years of age with a first NP diagnosis (index) and 365 days of baseline and >/=180 days of follow-up data. Follow-up continued until disenrollment, death or end of data collection. MAIN OUTCOME MEASURES: Primary: primary care physician prescribed CRSwNP-related treatments, and all-cause healthcare resource utilisation (HCRU) in 90 days post-index, stratified by surgeries during follow-up. Secondary: rate of surgery and CRSwNP point prevalence. Baseline patient demographics, clinical characteristics and comorbidities were also assessed. RESULTS: Of the 33 107 patients included, 23.5% and 2.2% had >/=1 and >/=2 surgeries during follow-up, respectively (mean follow-up: 5.3 years). Patients with more surgeries (>/=2/>/=1/0) during follow-up were more likely to be male (67.3%/69.0%/58.0%), have asthma (37.8%/28.2%/20.2%) and have baseline blood eosinophil counts >/=300 cells/muL (68.5%/66.0%/51.5%). During the first 90-days post-index as surgery number increased, the proportion of patients using oral corticosteroids (25.8%/20.7%/14.2%) and mean (SD) number of all-cause healthcare visits (5.9 [4.2]/5.4 [4.0]/4.9 [4.2]) increased. Time between surgeries was shorter among patients with more surgeries. CRSwNP prevalence on 31 December 2018 was 476 cases per 100 000 persons. CONCLUSION: A small proportion of patients in the UK required multiple surgeries for CRSwNP and this was associated with increasing comorbidity burden, baseline blood eosinophil counts, CRSwNP-related treatment and HCRU use. |
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| ジャーナル名 | Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery |
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| Pubmed追加日 | 2023/5/2 |
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| 投稿者 | Benson, Victoria S; Fu, Qinggong; Yang, Shibing; Sousa, Ana R; Chan, Robert H; Howarth, Peter; Hopkins, Claire |
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| 組織名 | Epidemiology, Value Evidence and Outcomes, GSK, GSK House, Brentford, Middlesex,;UK.;Value Evidence and Outcomes, GSK, Collegeville, Pennsylvania, USA.;Respiratory Clinical Sciences R&D, GSK House, Brentford, Middlesex, UK.;Global Medical Affairs, GSK, Brentford, Middlesex, UK.;ENT Department, Guys and St Thomas's Hospital, London, UK.;King's College Hospital, London, UK. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37129235/ |
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