| アブストラクト | Antibacterial drug exposure (ADE) is a well-known potential risk factor for Clostridium difficile infection (CDI), but it remains controversial which certain antibacterial drugs are associated with the highest risk of CDI occurrence. To summarize CDI risk associated with ADE, we reviewed the CDI reports related to ADE in the FDA Adverse Event Reporting System database and conducted disproportionality analysis to detect adverse reaction (ADR) signals of CDI for antibacterial drugs. A total of 8063 CDI reports associated with ADE were identified, which involved 73 antibacterial drugs. Metronidazole was the drug with the greatest number of reports, followed by vancomycin, ciprofloxacin, clindamycin and amoxicillin. In disproportionality analysis, metronidazole had the highest positive ADR signal strength, followed by vancomycin, cefpodoxime, ertapenem and clindamycin. Among the 73 antibacterial drugs, 58 showed at least one positive ADR signal, and ceftriaxone was the drug with the highest total number of positive signals. Our study provided a real-world overview of CDI risk for AED from a pharmacovigilance perspective and showed risk characteristics for different antibacterial drugs by integrating its positive-negative signal distribution. Meanwhile, our study showed that the CDI risk of metronidazole and vancomycin may be underestimated, and it deserves further attention and investigation. |
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| ジャーナル名 | Antibiotics (Basel, Switzerland) |
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| 投稿日 | 2023/7/29 |
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| 投稿者 | Li, Dongxuan; Song, Yi; Bai, Zhanfeng; Xi, Xin; Liu, Feng; Zhang, Yang; Qin, Chunmeng; Du, Dan; Du, Qian; Liu, Songqing |
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| 組織名 | Department of Pharmacy, The Third Affiliated Hospital of Chongqing Medical;University, Chongqing 401120, China.;College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.;Center for Medical Information and Statistics, The Third Affiliated Hospital of;Chongqing Medical University, Chongqing 401120, China.;Medical Data Science Academy, Chongqing Medical University, Chongqing 400016,;China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/37508205/ |
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