| アブストラクト | PURPOSE: To describe the real-world treatment patterns of systemic therapies for biliary tract cancer (BTC) and to examine the frequency and management of biliary infection in Japan. METHODS: Patients diagnosed with BTC and prescribed systemic therapy between January 2011 and September 2020 were retrieved from the Japanese Medical Data Vision database. The look-back period was set to 5 years. Patient characteristics, treatment patterns, and biliary infection-induced treatment interruption were analyzed. RESULTS: The full analysis set comprised 22 742 patients with a mean age of 71.0 years and 61.6% were male. The most common BTC type was extrahepatic cholangiocarcinoma (44.6%). The three most common first-line regimens were S-1 monotherapy (33.0%), gemcitabine+cisplatin (32.5%), and gemcitabine monotherapy (18.7%) over the entire observation period (January 2011-September 2021). Patients who received monotherapies tended to be older. Biliary infection-induced treatment interruption occurred in 29.5% of patients, with a median time to onset of 64.0 (interquartile range 29.0-145.0) days. The median duration of intravenous antibiotics was 12.0 (interquartile range 4.0-92.0) days. CONCLUSIONS: These results demonstrated potential challenges of BTC in Japanese clinical practice particularly use of multiple regimens, commonly monotherapies, which are not recommended as first-line treatment, and the management of biliary infections during systemic therapy. |
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| ジャーナル名 | Journal of hepato-biliary-pancreatic sciences |
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| 投稿日 | 2024/7/2 |
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| 投稿者 | Ueno, Makoto; Shirakawa, Sachiyo; Tokumaru, Jumpei; Ogi, Mizue; Nishida, Kenichiro; Hirai, Takehiro; Shinozaki, Kenta; Hamada, Yoko; Kitagawa, Hiroshi; Horiguchi, Akihiko |
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| 組織名 | Department of Gastroenterology, Hepatobiliary and Pancreatic Medical Oncology;Division, Kanagawa Cancer Center, Yokohama, Japan.;Oncology Medical, AstraZeneca K.K., Osaka, Japan.;Evidence and Observational Research, Medical, AstraZeneca K.K., Osaka, Japan.;Department of Gastroenterological Surgery, Fujita Health University School of;Medicine, Nagoya, Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38953871/ |
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