| アブストラクト | PURPOSE AND DESIGN: This study aimed to evaluate the risk of drug-related dry eye using real-world data, underscoring the significance of tracing pharmacological etiology for distinct clinical types of dry eye. METHODS: Analyzing adverse event reports in the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to September 2023, we employed disproportionality analysis and the Bayesian confidence propagation neural network algorithm. The analysis involved categorizing drugs causing dry eye, assessing risk levels, and conducting segmental assessments based on the time of onset of drug-related dry eye adverse reactions. RESULTS: In the FAERS database, adverse reactions related to dry eye were linked to 1160 drugs. Disproportionality analysis identified 33 drugs with significant risk, notably in ophthalmic (brimonidine, bimatoprost), oncology (tisotumab vedotin, erdafitinib), and other medications (isotretinoin, oxymetazoline). The top three drugs with the highest risk of drug-related dry eye are isotretinoin (Bayesian confidence propagation neural network (BCPNN) = 6.88), tisotumab vedotin (BCPNN = 6.88), and brimonidine (BCPNN = 6.77). Among different categories of drugs, respiratory medications have the shortest mean onset time for drug-related dry eye, averaging 50.99 days. The prevalence skewed towards females (69.9 %), particularly in menopausal and elderly individuals (45-70 years old, mean age 54.7 +/- 18.2). Reports of drug-related dry eye adverse reactions showed an annual increase. CONCLUSION: Informed clinical decision-making is crucial for preventing drug-related dry eye. Assessing the risk of dry eyes associated with both local and systemic medications helps optimize treatment and provide necessary cautionary information. |
|---|
| ジャーナル名 | Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) |
|---|
| 投稿日 | 2024/9/30 |
|---|
| 投稿者 | Wu, Shi-Nan; Huang, Caihong; Wang, Yu-Qian; Chen, Xiao-Dong; Li, Xiang; Zhang, Si-Qi; Qin, Dan-Yi; Zhu, Linfangzi; Xu, Chang-Sheng; Zhang, Qing-He; Hu, Jiaoyue; Liu, Zuguo |
|---|
| 組織名 | Xiamen University affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory;of Ophthalmology and Visual Science, Fujian Engineering and Research Center of;Eye Regenerative Medicine, Eye Institute of Xiamen University, School of;Medicine, Xiamen University, Xiamen, Fujian 361005, China.;Department of Oncology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian;361005, China.;Department of Ophthalmology, the First Affiliated Hospital of University of South;China, Hengyang, Hunan 421001, China.;Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of;Ophthalmology, Xiang'an Hospital of Xiamen University, Xiamen, Fujian;361005, China. Electronic address: mydear_22000@163.com.;Ophthalmology, the First Affiliated Hospital of University of South;China, Hengyang, Hunan 421001, China; Department of Ophthalmology, Xiang'an;Hospital of Xiamen University, Xiamen, Fujian 361005, China. Electronic address:;zuguoliu@xmu.edu.cn. |
|---|
| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/39343068/ |
|---|
