| アブストラクト | OBJECTIVE: Although numerous drugs have been associated with cataracts, the risk for most drugs remains unclear. This study aimed to investigate the risk factors for drug-induced cataracts by analyzing large-scale data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). METHODS: We used the reporting odds ratio (ROR) to evaluate reports of drug-induced cataracts in FAERS from the first quarter of 2004 to the third quarter of 2024. A univariate analysis, LASSO (least absolute shrinkage and selection operator) regression, and a multivariate regression analysis were performed to identify drug-related risk factors for cataracts, and Bonferroni correction was applied for multiple comparisons. RESULTS: Multivariate logistic regression ultimately identified 15 drugs as independent risk factors, including immunomodulators (6/15), antineoplastic drugs (3/15), psychotropic drugs (1/15), respiratory drugs (1/15), gastrointestinal drugs (1/15), orthopedic drugs (1/15), metabolic regulators (1/15), and ophthalmic drugs (1/15). The median time to onset of drug-induced cataracts was 449 days (interquartile range [IQR]: 150-901 days), with approximately 75% of adverse events occurring within 747 days. CONCLUSION: These findings may help clinicians detect drug-related cataracts at an early stage and provide valuable insights for future research on the mechanisms of drug-induced cataracts. |
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| ジャーナル名 | Frontiers in pharmacology |
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| Pubmed追加日 | 2025/5/9 |
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| 投稿者 | Li, Xiang; Wang, Shu Wen; Zhang, Zhi-Jie; Luo, Zhan Yang; Tang, Jia Feng; Tao, Tao |
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| 組織名 | Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen;University, Xiamen, Fujian, China.;Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal;Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College,;Wan Zhou, China.;Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai,;China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40343006/ |
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