| アブストラクト | Drug-related conjunctivitis can compromise ocular health and quality of life. To evaluate its epidemiology, we analyzed reports from the FDA Adverse Event Reporting System (FAERS) spanning January 2004 to June 2024. The control group in this study comprised individuals using non-target drugs, while the experimental group consisted of individuals using target drugs. Using disproportionality analysis, we identified drugs with a positive signal for conjunctivitis and stratified their risk levels; we also examined induction periods to assess the speed of onset. Among 38 drugs most frequently reported for conjunctivitis, two ophthalmic agents-brimonidine (ROR = 23.04) and latanoprost (ROR = 10.55)-and eight non-ophthalmic drugs, including tralokinumab (ROR = 83.3), dupilumab (ROR = 18.92), and allopurinol (ROR = 5.04), were associated with positive signals. Tralokinumab, brimonidine, dupilumab, and latanoprost were identified as high-association medications. Notably, ophthalmic agents had a significantly shorter induction period than non-ophthalmic drugs (mean 125.9 vs. 298.4 days). These findings underscore the need for vigilant pharmacovigilance and further investigation into the etiology and prevention of drug-related conjunctivitis. |
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| ジャーナル名 | Scientific reports |
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| Pubmed追加日 | 2025/4/19 |
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| 投稿者 | Li, Xiang; Sun, Yi-Qing; Liu, Miao-Miao; Tang, Jia-Feng |
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| 組織名 | Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen;University, Xiamen, Fujian, China.;Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal;Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College,;No. 366, Tian Xing Rd, Bai'anba, Wan Zhou, Chongqing, 404120, China.;The First Affiliated Hospital of Xi'an Jiao Tong University, Xi An, 710061,;Shaanxi, China.;57094644@qq.com. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/40251175/ |
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