| アブストラクト | BACKGROUND: Perinatal depression (PND) is a prevalent and serious mental health concern affecting women during pregnancy and the postpartum period. Although several drugs have been implicated in PND etiology in previous studies, large-scale systematic evaluations of drug-associated PND using real-world pharmacovigilance data remain scarce. METHODS: We conducted a retrospective pharmacovigilance study utilizing the FDA Adverse Event Reporting System data spanning from Q1 2004 to Q2 2025. Disproportionality analysis, logistic regression, LASSO regression, and time-to-onset analysis were employed to examine drug-PND associations from multiple analytical perspectives. RESULTS: Disproportionality analyses identified 28 drugs with positive signals as potentially associated with PND. Multi-factor analysis identified age under 26 years, weight exceeding 74 kg, and use of sodium oxybate, levonorgestrel, ethinylestradiol/etonogestrel, or lurasidone as independent risk factors for drug-related PND. The model achieved a ROC-AUC of 0.907, indicating excellent discriminatory performance. CONCLUSION: This study identified specific drugs and demographic factors associated with PND risk, offering valuable insights for pharmacovigilance and clinical medication management. |
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| ジャーナル名 | Frontiers in pharmacology |
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| Pubmed追加日 | 2026/5/11 |
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| 投稿者 | Chen, Jie-Hai; Luo, Qing-Ming; Tu, Yuan-Yan |
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| 組織名 | Department of Anesthesiology, Dongguan Maternal and Child Healthcare Hospital,;Dongguan, Guangdong, China.;Dongguan Maternal and Child Healthcare Hospital, Dongguan, Guangdong, China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/42110529/ |
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