| アブストラクト | OBJECTIVES: To investigate current patterns and outcomes of intravesical bacillus Calmette-Guerin treatment in Japanese patients with bladder cancer, including the proportion of patients completing induction therapy, and time to subsequent treatments. METHODS: This retrospective cohort study utilized administrative claims data from the Medical Data Vision Co., Ltd. database to identify patients with a diagnosis of bladder cancer who had received >/=1 prescription of intravesical bacillus Calmette-Guerin between April 2008 and September 2015, and had >/=1 database record dated >/=12 weeks after the initial bacillus Calmette-Guerin dose. Patients were followed until September 2018, the last date of available data, or in-hospital death. Patients receiving six doses of bacillus Calmette-Guerin at intervals of <21 days were considered to have completed induction according to guidelines. Time from initial bacillus Calmette-Guerin dose to subsequent bladder cancer treatment after the end of treatment was defined as the recurrence-free duration. RESULTS: Of 6140 patients identified (median age 73.0 years; 83.4% males), 4588 (74.7%) completed induction and 1552 (25.3%) did not. Median recurrence-free duration was 64.4, 77.7, and 31.6 months in the overall, complete-induction and incomplete-induction cohorts, respectively. Corresponding 3-year recurrence-free rate was 56.3%, 59.0%, and 48.2% in these groups. The rate of cystectomy was approximately 6% at 5 years in all cohorts. CONCLUSIONS: Approximately 75% of Japanese patients who undergo intravesical bacillus Calmette-Guerin treatment receive a guideline-compliant induction regimen, but outcomes were not satisfactory, highlighting the need for more effective treatments for non-muscle invasive bladder cancer. |
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| ジャーナル名 | International journal of urology : official journal of the Japanese Urological Association |
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| 投稿日 | 2022/5/23 |
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| 投稿者 | Miyake, Makito; Kikuchi, Eiji; Shinozaki, Kenta; Piao, Yi; Hayashi, Nobuya; Koto, Ryo; Jinushi, Masahisa; Kobayashi, Takashi |
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| 組織名 | Department of Urology, Nara Medical University, Nara, Japan.;Department of Urology, St. Marianna University School of Medicine, Kanagawa,;Japan.;AstraZeneca K.K., Osaka, Japan.;Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/35598101/ |
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