| アブストラクト | BACKGROUND: Asthma-related burden remains poorly characterised in children in the UK. We quantified recent trends in asthma prevalence and burden in a UK population-based cohort (1 E7-year-olds). METHODS: The Clinical Practice Research Datalink Aurum database (2008 E018) was used to assess annual asthma incidence and prevalence in 1 E7-year-olds and preschool wheeze in 1 E-year-olds, stratified by sex and age. During the same period, annual asthma exacerbation rates were assessed in those with either a diagnosis of preschool wheeze or asthma. RESULTS: Annual asthma incidence rates decreased by 51% from 1403.4 (95% CI 1383.7 to 1423.2) in 2008 to 688.0 (95% CI 676.3 to 699.9) per 10(5) person-years (PYs) in 2018, with the most pronounced decrease observed in 1 E-year olds (decreasing by 65%, from 2556.9 (95% CI 2509.8 to 2604.7) to 892.3 (95% CI 866.9 to 918.3) per 10(5) PYs). The corresponding decreases for the 6 E1- and 12 E7-year-olds were 36% (1139.9 (95% CI 1110.6 to 1169.7) to 739.9 (95% CI 720.5 to 759.8)) and 20% (572.3 (95% CI 550.4 to 594.9) to 459.5 (95% CI 442.9 to 476.4)) per 10(5) PYs, respectively. The incidence of preschool wheeze decreased over time and was slightly more pronounced in the 1 E year-olds than in the 4-year-olds. Prevalence of asthma and preschool wheeze also decreased over time, from 18.0% overall in 2008 to 10.2% in 2018 for asthma. Exacerbation rates increased over time from 1.33 (95% CI 1.31 to 1.35) per 10 PYs in 2008 to 1.81 (95% CI 1.78 to 1.83) per 10 PYs in 2018. CONCLUSION: Paediatric asthma incidence decreased in the UK since 2008, particularly in 1-5-year-olds; this was accompanied by a decline in asthma prevalence. Preschool wheeze incidence also decreased in this age group. However, exacerbation rates have been increasing. |
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| 投稿者 | Kallis, Constantinos; Maslova, Ekaterina; Morgan, Ann D; Sinha, Ian; Roberts, Graham; van der Valk, Ralf J P; Quint, Jennifer K; Tran, Trung N |
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| 組織名 | Faculty of Medicine, National Heart and Lung Institute, Imperial College London,;London, UK.;BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK.;Alder Hey Children's Hospital, Liverpool, UK.;Division of Child Health, University of Liverpool, Liverpool, UK.;University of Southampton Faculty of Medicine, Southampton, UK.;NIHR Southampton, Biomedical Research Centre, University Hospital Southampton,;Southampton, UK.;David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, UK.;Biopharmaceuticals Medical, Respiratory and Immunology, AstraZeneca,;Gaithersburg, Maryland, USA trung.tran1@astrazeneca.com. |
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