| アブストラクト | OBJECTIVE: The aim of this study is to provide guidance for refining medication protocols, developing alternative strategies, and enhancing protection against herpesvirus infections in personalized clinical settings. METHODS: Adverse drug events (ADEs) data for anti-herpesvirus from the first quarter of 2004 to the fourth quarter of 2022 were collected from the FDA Adverse Event Reporting System (FAERS). Disproportionality analysis was performed using Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), and Bayesian Confidence Propagation Neural Network (BCPNN) methods for data mining. RESULTS: A total of 18,591, 24,206, 6,150, and 419 reports of ADEs associated with acyclovir (ACV), valacyclovir (VACV), ganciclovir (GCV), and famciclovir (FCV) were screened and extracted from the FAERS. In this study, the report summarized the high frequency and strong correlation of ADEs for the four drugs at the Preferred Term (PT) level. Additionally, the analysis also identified the relationship between ADEs and factors such as age, gender, and severity of outcome at the System Organ Class (SOC) level. CONCLUSION: The safety reports for the four-nucleoside analogue anti-herpesvirus drugs are diverse and interconnected. Dosing for patients with herpesvirus infections should be tailored to their specific conditions and the potential risk of disease. |
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| ジャーナル名 | Expert opinion on drug safety |
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| 投稿日 | 2024/6/29 |
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| 投稿者 | Gao, Caixia; Dong, Xiaomei; Zhang, Jun; Mao, Lejiao; Guo, Changxin; Qin, Xia; Zou, Zhen |
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| 組織名 | Molecular Biology Laboratory of Respiratory Disease, Key Laboratory of Clinical;Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine,;Chongqing Medical University, Chongqing, P.R. China.;Research Center for Environment and Human Health, School of Public Health,;Chongqing Medical University, Chongqing, People's Republic of China.;Department of Health Laboratory Technology, School of Public Health, Chongqing;Medical University, Chongqing, People's Republic of China.;Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical;University, Chongqing, People's Republic of China. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38943630/ |
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