| アブストラクト | Red yeast rice (RYR) is a dietary supplement containing monacolins obtained by fermentation of Monascus purpureus strains. Because of its structural homology with lovastatin, monacolin K inhibits HMG-CoA reductase and shows hypocholesterolemic properties comparable to synthetic statins. We studied all cases of myopathy involving RYR reported in the French national pharmacovigilance database (6 cases) and in scientific literature (9 cases). Among these cases, 9 showed elevated creatine kinase, 3 rhabdomyolysis and 2 myalgia. Recent studies seem to show good efficacy of the RYR, however, our work reports the existence of related muscular disorders. In addition, dietary supplements currently available on the market may show considerable variability of formulation and/or the presence of contaminants. When clinicobiological disorders occur, physicians should consider the eventual use of an herbal treatment. |
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| ジャーナル名 | Therapie |
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| 投稿日 | 2017/3/10 |
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| 投稿者 | Philibert, Christelle; Bres, Virginie; Jean-Pastor, Marie-Josephe; Guy, Claire; Lebrun-Vignes, Benedicte; Robin, Perrine; Pinzani, Veronique; Hillaire-Buys, Dominique |
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| 組織名 | Departement de pharmacologie medicale et toxicologie, centre regional de;pharmacovigilance et d'information sur le medicament, hopital Lapeyronie, CHU;Lapeyronie, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 5,;France. Electronic address: c-philibert@chu-montpellier.fr.;France.;Centre regional de pharmacovigilance et d'information sur le medicament, hopital;Sainte-Marguerite, 13009 Marseille, France.;Nord, CHU de Saint-Etienne, 42270 Saint-Priest-en-Jarez, France.;Coordination de pharmacovigilance d'Ile-de-France, centre regional de;pharmacovigilance et d'information sur le medicament, hopital de la;Pitie-Salpetriere, 75013 Paris, France. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/28277227/ |
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