| アブストラクト | OBJECTIVES: To assess whether children with autism are more likely to have a history of gastrointestinal disorders than children without autism. DESIGN: Nested case-control study. SETTING: UK General Practice Research Database. SUBJECTS: Children born after 1 January 1988 and registered with the General Practice Research Database within 6 months of birth. OUTCOME MEASURES: Chronic inflammation of the gastrointestinal tract, coeliac disease, food intolerance, and recurrent gastrointestinal symptoms recorded by the general practitioner. RESULTS: 9 of 96 (9%) children with a diagnosis of autism (cases) and 41 of 449 (9%) children without autism (matched controls) had a history of gastrointestinal disorders before the index date (the date of first recorded diagnosis of autism in the cases and the same date for controls). The estimated odds ratio for a history of gastrointestinal disorders among children with autism compared with children without autism was 1.0 (95% confidence interval 0.5 to 2.2). CONCLUSIONS: No evidence was found that children with autism were more likely than children without autism to have had defined gastrointestinal disorders at any time before their diagnosis of autism. |
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| ジャーナル名 | BMJ (Clinical research ed.) |
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| Pubmed追加日 | 2002/8/24 |
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| 投稿者 | Black, Corri; Kaye, James A; Jick, Hershel |
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| 組織名 | Boston Collaborative Drug Surveillance Program, Boston University School of;Medicine, MA 02421, USA. cxb2@ph.abdn.ac.uk |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/12193358/ |
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