Renal function and oral anticoagulant treatment of incident non-valvular atrial fibrillation: a retrospective study.
Aim: To describe the renal function of individuals newly diagnosed with non-valvular atrial fibrillation (NVAF) in England, and describe how oral anticoagulant (OAC) treatment varies according to renal function. Patients & methods: We identified a cohort of individuals with non-valvular atrial fibrillation (n = 18,419) and described their renal function at diagnosis and the prevalence of OAC treatment initiation by renal function.
Results: 79% of individuals had some evidence of renal dysfunction with 12% having a glomerular filtration rate <30 ml/min/1.73 m(2). OAC treatment initiation in the 6 months following diagnosis was lower in individuals with severe renal dysfunction than in those with normal renal function.
Conclusion: The high prevalence of renal dysfunction and low OAC treatment prevalence highlights the need for additional evidence regarding OACs in individuals with severe renal dysfunction.
|投稿者||Ramagopalan, Sreeram V; Stamp, Elaine; Sammon, Cormac J; Besford, Megan; Carroll, Robert; Mehmud, Faisal; Alikhan, Raza|
|組織名||Centre for Observational Research & Data Sciences, Bristol-Myers Squibb, UB8 1DH,;UK.;PHMR, Berkeley Works, London, NW1 8XY, UK.;Bristol-Myers Squibb, Uxbridge, UB8 1DH, UK.;Department of Haematology, University Hospital of Wales, Cardiff & Vale;University Health Board, Cardiff, CF14 4XW, UK.|