| アブストラクト | AIM: To evaluate whether sodium-glucose cotransporter 2 inhibitor (SGLT2i) therapy is associated with a reduction of renal events compared with other glucose-lowering drugs (oGLDs) among Japanese people with type 2 diabetes (T2D) and grade 3 (G3) chronic kidney disease (CKD) in a real-world clinical practice setting. MATERIALS AND METHODS: People with T2D who were newly prescribed an SGLT2i or an oGLD from April 2014 to November 2021 (without prior use of index drugs for >/= 1 year prior to index date) and G3 CKD (estimated glomerular filtration rate [eGFR] >/= 30 to < 60 mL/min/1.73 m(2)) were selected from the Medical Data Vision database (MDV-DB) and the Real-World Data database (RWD-DB). SGLT2i and oGLD users were matched (1:1) using propensity score on patient background characteristics. The primary endpoint was a composite of the development of end-stage kidney disease or a sustained decline in eGFR of 50% or more. Hazard ratios (HRs) were estimated using the Cox proportional hazards model. RESULTS: Overall, 3190 (1595 per group) patients in the MDV-DB and 2572 (1286 per group) patients in the RWD-DB were included in the analyses. The composite outcome was significantly lower in the SGLT2i group than in the oGLD group in the MDV-DB (HR 0.49, 95% confidence interval [CI] 0.33 to 0.74, P < 0.001) and in the RWD-DB (HR 0.57, 95% CI 0.37 to 0.88, P = 0.011). CONCLUSIONS: Japanese people with T2D and G3 CKD initiating an SGLT2i had a lower risk of renal events than people initiating an oGLD. |
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| ジャーナル名 | Diabetes, obesity & metabolism |
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| 投稿日 | 2024/2/28 |
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| 投稿者 | Iijima, Hiroaki; Gouda, Maki; Hida, Hideaki; Mori-Anai, Kazumi; Takahashi, Akiko; Minai, Ryoichi; Ninomiya, Hideki; Saito, Yoshiyuki; Miyawaki, Atsushi; Wada, Jun |
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| 組織名 | Ikuyaku. Integrated Value Development Division, Mitsubishi Tanabe Pharma;Corporation, Tokyo, Japan.;Datack, Inc., Tokyo, Japan.;Department of Public Health, Graduate School of Medicine, The University of;Tokyo, Tokyo, Japan.;Department of Health Services Research, Graduate School of Medicine, The;University of Tokyo, Tokyo, Japan.;Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Faculty of;Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama,;Japan. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/38413384/ |
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