| アブストラクト | BACKGROUND: Patients with chronic or acute/postoperative pain frequently use opioids. However, opioids may cause considerable adverse reactions (ARs), such as respiratory depression, which could be lethal. Unfortunately, only 5% of drug-related ARs (including those to opioids) are reported to health authorities. Therefore, little is known regarding the occurrence of opioid-related ARs at the population level. OBJECTIVE: The aim of this study was to investigate how the rates of reported opioid-related ARs have changed in Canada since 1965. METHODS: Our retrospective study examined trends of reported opioid-related ARs occurring in hospitalized and outpatients. Data on opioid-related ARs and mortality between 1965 and 2019 were obtained from the Canada Vigilance and Statistics Canada databases. Descriptive and Joinpoint regression analyses were performed. RESULTS: Oxycodone and normethadone were the most and least involved opioid agents, respectively, among the 18,407 reported ARs. The highest rate of reported opioid ARs (3.8 per 100,000 person-years) was recorded in 2012, whereas the lowest was recorded in 1965 (0.1 per 100,000 person-years). Between 1965 and 2019, annual rates climbed by 4.2% (95% confidence interval [CI] 3.1-5.2), and many fluctuations were observed: 1965-1974: +22.3% (95% CI 12.0-33.6); 1974-2000: - 4.1% (95% CI - 5.3 to - 2.9); 2000-2008: +30.3% (95% CI 22.6-38.4); 2008-2014: +4.1% (95% CI - 1.5 to 10.1); 2014-2017: -26.0% (95% CI - 44.7 to - 0.9); and, finally, 2017-2019: +35.4% (95% CI 3.8-76.7). CONCLUSION: Reported opioid-related ARs have increased since 1965, although fluctuations were observed in recent decades. The absolute number of opioid-related ARs might be seriously underestimated. Future studies should look into how to close this gap. |
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| ジャーナル名 | Drugs - real world outcomes |
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| 投稿日 | 2021/9/17 |
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| 投稿者 | Lavallee, Maude; da Silveira, Carolina Galli; Akinola, Samuel; Methot, Julie; Piche, Marie-Eve; Berard, Anick; Thibault, Magalie; Gonella, Jennifer Midiani; Gimenes, Fernanda Raphael Escobar; Leclerc, Jacinthe |
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| 組織名 | Departement des Sciences infirmieres, Universite du Quebec a Trois-Rivieres,;3351, boul. des Forges, C.P. 500, Trois-Rivieres, QC, G9A 5H7, Canada.;Ribeirao Preto College of Nursing, University of Sao Paulo, Ribeirao Preto,;Brazil.;Department of Nursing, Faculty of Health Sciences, University of Pecs, Pecs,;Hungary.;Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie;de Quebec-Universite Laval, Quebec City, Canada.;Faculty of Pharmacy, Universite Laval, Quebec City, Canada.;Faculty of Medicine, Universite Laval, Quebec City, Canada.;Centre de recherche du Centre Hospitalier Universitaire Ste-Justine, Montreal,;Canada.;Faculty of Pharmacy, Universite de Montreal, Montreal, Canada.;jacinthe.leclerc@uqtr.ca.;de Quebec-Universite Laval, Quebec City, Canada. jacinthe.leclerc@uqtr.ca. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/34529224/ |
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