| アブストラクト | OBJECTIVE: We sought to determine the frequency of represcription of penicillin to individuals with penicillin allergy and the risk of a second reaction in those who had a previous reaction. METHODS: A retrospective cohort study was conducted within the UK General Practice Research Database. All patients who had received a prescription for penicillin were identified. Within that source population, records of patients who had received at least 2 prescriptions for penicillin at least 60 days apart were selected and examined for allergic-like (hypersensitivity) events on the day of or within 30 days after a prescription. RESULTS: At least one prescription for penicillin was given to 3,375,162 patients. Of 6212 (0.18%) patients who experienced an allergic-like event after the initial prescription, 48.5% were given a second prescription compared with 59.8% of those without an initial allergic-like event (risk ratio, 0.81; 95% CI, 0.79-0.83). Two or more prescriptions for penicillin were given to 2,017,957 patients. Three thousand fourteen (0.15%) patients experienced an allergic-like event after the first prescription, and 57 (1.89%) of those had another event after the second prescription. The unadjusted odds ratio of an allergic-like event after the second prescription for those who experienced an allergic-like event after the first prescription, compared with those who had no initial event was 11.2 (95% CI, 8.6-14.6). Adjusting for confounding had no substantive effect on this result. CONCLUSION: The risk of an allergic-like event after penicillin is markedly increased in those who have had a prior event, although the absolute difference is small (1.72%). Represcription of penicillin to such patients is more frequent than anticipated. |
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| ジャーナル名 | The Journal of allergy and clinical immunology |
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| 投稿日 | 2004/04/22 |
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| 投稿者 | Apter, Andrea J; Kinman, Judith L; Bilker, Warren B; Herlim, Maximilian; Margolis, David J; Lautenbach, Ebbing; Hennessy, Sean; Strom, Brian L |
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| 組織名 | Division of Pulmonary, Allergy, and Critical Care Medicine, Department of;Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104,;USA. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/15100685/ |
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