| アブストラクト | With the spread of the new SARS-CoV-2 variants, many countries have begun COVID-19 vaccine booster programs with the mix-and-match strategy. However, research on the adverse events (AE) of booster doses is still scarce. The aim of our study was to analyze the reported incidence rate (IR), and factors associated with AE, including short-term serious adverse events (SAE) and short-term non-serious adverse events (NSAE), among different vaccine products through the hospital-based Vaccine Adverse Event Reporting System (VAERS). A total of 7432 records were collected during the three-month study period. While more than half of the responses (52.2%) reported the presence of AE after receiving a booster dose, only a few AE were considered SAE (2.4%). AE were significantly higher among women and people of younger age, and the brand of vaccines is the strongest factor associated with post-booster dose AE. The incidence of AE in mRNA1273 is higher than in BNT162b2 and MVC-COV1901 (IRR mRNA1273 vs. BNT162b2: 1.22, 95% CI: 1.11-1.34; BNT162b2 vs. MVC-COV1901: 2.77, 95% CI: 2.27-3.39). The IR of different groups were calculated to support the decision making of the booster vaccine. Although AE were not uncommon for booster vaccines, almost all AE were not serious and predictable using estimated IR. This result can be used to optimize booster vaccine decision making. |
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| 投稿者 | Chen, Po-Yu; Wu, Bih-Ju; Su, Mei-Chin; Lin, Yen-Hsi; Chiang, Shu-Chiung; Wu, Jau-Ching; Chen, Tzeng-Ji; Chen, Yu-Chun |
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| 組織名 | Department of Family Medicine, Taipei Veterans General Hospital, Taipei 112,;Taiwan.;School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.;Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan.;Institute of Hospital and Health Care Administration, School of Medicine,;National Yang Ming Chiao Tung University, Taipei 112, Taiwan.;Department of Neurosurgery, Neurological Institute, Taipei Veterans General;Hospital, Taipei 112, Taiwan.;Big Data Center, Taipei Veterans General Hospital, Taipei 112, Taiwan.;Department of Family Medicine, Taipei Veterans General Hospital, Hsinchu Branch,;Hsinchu 31064, Taiwan. |
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