| アブストラクト | We conducted a cohort study with a nested case-control analysis to evaluate the effect of anti-inflammatory drugs in breast cancer incidence using the General Practice Research Database. Women taking aspirin and paracetamol for 1 year or longer had an odds ratio (OR) of 0.77 (95 percent confidence interval (95% CI): 0.62,0.95) and 0.76 (95% CI: 0.65,0.88), respectively, compared to nonusers. Daily doses of aspirin (75 mg) and paracetamol (up to 2000 mg) showed the greatest reduced risk. Use of non-aspirin nonsteroidal anti-inflammatory drugs for more than 1 year was not associated with a reduced risk of breast cancer (OR=1.00 (95% CI: 0.84, 1.17), and the corresponding estimate among users with at least 2 years duration was similar. Our findings suggest that aspirin at cardioprophylactic doses as well as paracetamol at analgesic doses is associated with a reduced risk of breast cancer. |
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| ジャーナル名 | British journal of cancer |
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| Pubmed追加日 | 2004/7/1 |
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| 投稿者 | Garcia Rodriguez, L A; Gonzalez-Perez, A |
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| 組織名 | Centro Espanol de Investigacion Farmacoepidemiologica (CEIFE), C/Almirante 28 2,;28004 Madrid, Spain. |
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| Pubmed リンク | https://www.ncbi.nlm.nih.gov/pubmed/15226764/ |
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